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- W2076177910 abstract "Previous studies have suggested that women with PCOS may benefit from statin therapy as it has shown to decrease serum testosterone levels especially in subjects with hyperandrogenism. However, the data concerning the effects of statin therapy on glucose tolerance in PCOS have been controversial. The purpose of the present study was to explore the effects of atorvastatin therapy on glucose metabolism, androgens, lipid profile and chronic inflammation in women with PCOS. A randomized, double-blinded, placebo-controlled 6-month follow-up study. The diagnosis of PCOS was based on Rotterdam criteria. Twenty-eight of 38 women with PCOS completed the study; atorvastatin 20 mg/day (n=15) or placebo (n=13) for 6 months. Fasting serum samples were collected at baseline and thereafter at 3 and 6 months of treatment. Oral glucose tolerance tests (OGTTs) and intravenous glucose tolerance tests (IVGTTs) were performed at 0 and 6 months. Repeated measures ANOVA, Friedman's test and One-Way ANOVA were used for statistical analyses. Fasting insulin levels and area under the curve (during OGTT) increased and whole-body insulin sensitivity decreased significantly in the atorvastatin group. However, insulin sensitivity measured by IVGTT did not change in either group. Serum levels of dehydroepiandrosterone sulphate decreased in the atorvastatin group, whereas no change was observed in testosterone levels. Serum levels of C-reactive protein decreased significantly and lipid profile improved during statin therapy. Atorvastatin therapy improves lipid profile and chronic inflammation but impairs insulin sensitivity in women with PCOS. Since these women present with high risk of type 2 diabetes, the results suggest that statin therapy should be initiated based on generally accepted criteria and individual risk assessment of cardiovascular disease, and not only due to the diagnosis of PCOS." @default.
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- W2076177910 date "2012-09-01" @default.
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- W2076177910 title "Statin therapy impairs insulin sensitivity in women with polycystic ovary syndrome (PCOS): a prospective, randomized, double-blinded, placebo-controlled study" @default.
- W2076177910 doi "https://doi.org/10.1016/j.fertnstert.2012.07.007" @default.
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