Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076190018> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2076190018 endingPage "3655" @default.
- W2076190018 startingPage "3653" @default.
- W2076190018 abstract "Although previous studies have demonstrated that stromal-derived factor-1 (SDF-1) played a key role in chronic graft dysfunction (CGD), the precise mechanisms underlying this process are not clear. In this study, SDF-1 was injected into keratinocyte stem cells (KSCs) which were isolated and purified from neonatal C57BL/6 (H-2b) mice. Adenylyl cyclase (AC) activity of KSCs was measured and expressions of the human major histocompatibility complex (MHC) class I chain-related antigens A and B (MICA, MICB) detected by immunofluorescence. Cultured KSCs were negative for IA/IE MHC class II molecules by immunofluorescence, indicating the absence of any contamination with Langerhans cells and certifying the purity of KSCs. Over a 7-day culture period, SDF-1 up-regulated AC activity to 2.783 +/- 0.799, which was higher than that of the control group (1.290 +/- 0.476; P < .01). Immunostaining showed that KSCs expressed increased amounts of MICA protein (0.790 +/- 0.134 versus 0.200 +/- 0.022; P < .01) and MICB protein (0.610 +/- 0.832 versus 0.230 +/- 0.016; P < .01). Mixed lymphocyte reaction assays showed that KSCs cultured with SDF-1 injection for 7 days stimulated allogeneic T-cell proliferation. The data indicated that SDF-1 may accelerate the ultimate rejection of allogeneic keratinocytes by enhancing MIC through the AC signal pathway." @default.
- W2076190018 created "2016-06-24" @default.
- W2076190018 creator A5026488218 @default.
- W2076190018 creator A5043197958 @default.
- W2076190018 creator A5089309011 @default.
- W2076190018 creator A5089604978 @default.
- W2076190018 date "2008-12-01" @default.
- W2076190018 modified "2023-10-16" @default.
- W2076190018 title "Stromal-Derived Factor-1 Up-regulated the Expression of MIC on Mouse Keratinocyte Stem Cells" @default.
- W2076190018 cites W2006077088 @default.
- W2076190018 cites W2009488462 @default.
- W2076190018 cites W2012173650 @default.
- W2076190018 cites W2093692106 @default.
- W2076190018 cites W2120552228 @default.
- W2076190018 cites W2149729267 @default.
- W2076190018 cites W2157183207 @default.
- W2076190018 cites W2411570094 @default.
- W2076190018 doi "https://doi.org/10.1016/j.transproceed.2008.03.168" @default.
- W2076190018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19100459" @default.
- W2076190018 hasPublicationYear "2008" @default.
- W2076190018 type Work @default.
- W2076190018 sameAs 2076190018 @default.
- W2076190018 citedByCount "0" @default.
- W2076190018 crossrefType "journal-article" @default.
- W2076190018 hasAuthorship W2076190018A5026488218 @default.
- W2076190018 hasAuthorship W2076190018A5043197958 @default.
- W2076190018 hasAuthorship W2076190018A5089309011 @default.
- W2076190018 hasAuthorship W2076190018A5089604978 @default.
- W2076190018 hasConcept C126322002 @default.
- W2076190018 hasConcept C147483822 @default.
- W2076190018 hasConcept C153911025 @default.
- W2076190018 hasConcept C16930146 @default.
- W2076190018 hasConcept C202751555 @default.
- W2076190018 hasConcept C203014093 @default.
- W2076190018 hasConcept C204232928 @default.
- W2076190018 hasConcept C207936829 @default.
- W2076190018 hasConcept C2777074287 @default.
- W2076190018 hasConcept C28328180 @default.
- W2076190018 hasConcept C4224716 @default.
- W2076190018 hasConcept C502942594 @default.
- W2076190018 hasConcept C55493867 @default.
- W2076190018 hasConcept C71924100 @default.
- W2076190018 hasConcept C86803240 @default.
- W2076190018 hasConcept C95444343 @default.
- W2076190018 hasConceptScore W2076190018C126322002 @default.
- W2076190018 hasConceptScore W2076190018C147483822 @default.
- W2076190018 hasConceptScore W2076190018C153911025 @default.
- W2076190018 hasConceptScore W2076190018C16930146 @default.
- W2076190018 hasConceptScore W2076190018C202751555 @default.
- W2076190018 hasConceptScore W2076190018C203014093 @default.
- W2076190018 hasConceptScore W2076190018C204232928 @default.
- W2076190018 hasConceptScore W2076190018C207936829 @default.
- W2076190018 hasConceptScore W2076190018C2777074287 @default.
- W2076190018 hasConceptScore W2076190018C28328180 @default.
- W2076190018 hasConceptScore W2076190018C4224716 @default.
- W2076190018 hasConceptScore W2076190018C502942594 @default.
- W2076190018 hasConceptScore W2076190018C55493867 @default.
- W2076190018 hasConceptScore W2076190018C71924100 @default.
- W2076190018 hasConceptScore W2076190018C86803240 @default.
- W2076190018 hasConceptScore W2076190018C95444343 @default.
- W2076190018 hasIssue "10" @default.
- W2076190018 hasLocation W20761900181 @default.
- W2076190018 hasLocation W20761900182 @default.
- W2076190018 hasOpenAccess W2076190018 @default.
- W2076190018 hasPrimaryLocation W20761900181 @default.
- W2076190018 hasRelatedWork W1974516972 @default.
- W2076190018 hasRelatedWork W2059941788 @default.
- W2076190018 hasRelatedWork W2067097521 @default.
- W2076190018 hasRelatedWork W2134995196 @default.
- W2076190018 hasRelatedWork W2184399836 @default.
- W2076190018 hasRelatedWork W2321292830 @default.
- W2076190018 hasRelatedWork W2410258605 @default.
- W2076190018 hasRelatedWork W2414452049 @default.
- W2076190018 hasRelatedWork W2418466149 @default.
- W2076190018 hasRelatedWork W3178353381 @default.
- W2076190018 hasVolume "40" @default.
- W2076190018 isParatext "false" @default.
- W2076190018 isRetracted "false" @default.
- W2076190018 magId "2076190018" @default.
- W2076190018 workType "article" @default.