Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076194002> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2076194002 endingPage "666" @default.
- W2076194002 startingPage "657" @default.
- W2076194002 abstract "The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. In another test using anesthetized dogs, the cardiovascular effects of cumulative doses of SC-36602 were assessed. The direct negative inotropic potential of each drug was also determined using isolated cat papillary muscles. In the hemodynamic study, SC-36602 and quinidine did not cause significant myocardial depression, measured as a decrease in the maximal first derivative of the left ventricular pressure. (Heart rate and diastolic filling pressure were not controlled in order to mimic clinical conditions.) SC-36602, mexiletine, flecainide, and quinidine increased heart rate. SC-36602 and mexiletine caused a small increase in mean arterial pressure, whereas disopyramide and quinidine decreased it. Disopyramide was the only drug studied that increased left ventricular end-diastolic pressure. SC-36602, quinidine, and mexiletine increased index of cardiac effort. Disopyramide caused a decrease in the latter. Disopyramide, flecainide, encainide, and lorcainide lengthened the ECG intervals. Cumulative intravenous doses of SC-36602 up to 50 mg/kg produced significant decreases in mean arterial pressure, increases in heart rate, and increases in P-R and QRS intervals of the ECG relative to placebo-matched controls. SC-36602 had the least direct negative inotropic action of the drugs studied, as measured in isolated papillary muscles. These data suggest SC-36602, when compared to the other antiarrhythmic drugs studied, has the least amount of hemodynamic side-effects at its antiarrhythmic dose." @default.
- W2076194002 created "2016-06-24" @default.
- W2076194002 creator A5005028394 @default.
- W2076194002 creator A5013288443 @default.
- W2076194002 creator A5074231825 @default.
- W2076194002 creator A5075491539 @default.
- W2076194002 creator A5082374155 @default.
- W2076194002 date "1988-06-01" @default.
- W2076194002 modified "2023-10-04" @default.
- W2076194002 title "SC-36602, A New Antiarrhythmic Agent" @default.
- W2076194002 doi "https://doi.org/10.1097/00005344-198806000-00005" @default.
- W2076194002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2457760" @default.
- W2076194002 hasPublicationYear "1988" @default.
- W2076194002 type Work @default.
- W2076194002 sameAs 2076194002 @default.
- W2076194002 citedByCount "14" @default.
- W2076194002 crossrefType "journal-article" @default.
- W2076194002 hasAuthorship W2076194002A5005028394 @default.
- W2076194002 hasAuthorship W2076194002A5013288443 @default.
- W2076194002 hasAuthorship W2076194002A5074231825 @default.
- W2076194002 hasAuthorship W2076194002A5075491539 @default.
- W2076194002 hasAuthorship W2076194002A5082374155 @default.
- W2076194002 hasBestOaLocation W20761940021 @default.
- W2076194002 hasConcept C126322002 @default.
- W2076194002 hasConcept C155710745 @default.
- W2076194002 hasConcept C164705383 @default.
- W2076194002 hasConcept C2777561782 @default.
- W2076194002 hasConcept C2777953023 @default.
- W2076194002 hasConcept C2778131192 @default.
- W2076194002 hasConcept C2779161974 @default.
- W2076194002 hasConcept C2779831137 @default.
- W2076194002 hasConcept C2779837460 @default.
- W2076194002 hasConcept C2780074459 @default.
- W2076194002 hasConcept C2780149897 @default.
- W2076194002 hasConcept C2780339425 @default.
- W2076194002 hasConcept C42219234 @default.
- W2076194002 hasConcept C71924100 @default.
- W2076194002 hasConcept C84393581 @default.
- W2076194002 hasConceptScore W2076194002C126322002 @default.
- W2076194002 hasConceptScore W2076194002C155710745 @default.
- W2076194002 hasConceptScore W2076194002C164705383 @default.
- W2076194002 hasConceptScore W2076194002C2777561782 @default.
- W2076194002 hasConceptScore W2076194002C2777953023 @default.
- W2076194002 hasConceptScore W2076194002C2778131192 @default.
- W2076194002 hasConceptScore W2076194002C2779161974 @default.
- W2076194002 hasConceptScore W2076194002C2779831137 @default.
- W2076194002 hasConceptScore W2076194002C2779837460 @default.
- W2076194002 hasConceptScore W2076194002C2780074459 @default.
- W2076194002 hasConceptScore W2076194002C2780149897 @default.
- W2076194002 hasConceptScore W2076194002C2780339425 @default.
- W2076194002 hasConceptScore W2076194002C42219234 @default.
- W2076194002 hasConceptScore W2076194002C71924100 @default.
- W2076194002 hasConceptScore W2076194002C84393581 @default.
- W2076194002 hasIssue "6" @default.
- W2076194002 hasLocation W20761940021 @default.
- W2076194002 hasLocation W20761940022 @default.
- W2076194002 hasOpenAccess W2076194002 @default.
- W2076194002 hasPrimaryLocation W20761940021 @default.
- W2076194002 hasRelatedWork W2016760752 @default.
- W2076194002 hasRelatedWork W2043101449 @default.
- W2076194002 hasRelatedWork W2053938266 @default.
- W2076194002 hasRelatedWork W2073803875 @default.
- W2076194002 hasRelatedWork W2076194002 @default.
- W2076194002 hasRelatedWork W2085757478 @default.
- W2076194002 hasRelatedWork W2118944321 @default.
- W2076194002 hasRelatedWork W2158813745 @default.
- W2076194002 hasRelatedWork W2396740643 @default.
- W2076194002 hasRelatedWork W2436996972 @default.
- W2076194002 hasVolume "11" @default.
- W2076194002 isParatext "false" @default.
- W2076194002 isRetracted "false" @default.
- W2076194002 magId "2076194002" @default.
- W2076194002 workType "article" @default.