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- W2076194704 abstract "Antimitochondrial, anti-gp210, anti-sp100, and anticentromere antibodies are specifically detected in primary biliary cirrhosis (PBC). In clinical practice, they are useful for the diagnosis of PBC or for evaluating disease severity, clinical phenotype, and long-term outcome. In the typical or classical form of PBC which shows slow progressive loss of small bile ducts with a parallel increase in liver fibrosis, anti-gp210 antibodies are a strong risk factor for progression to jaundice and hepatic failure, whereas the presence of anticentromere antibodies is a risk factor for progression to cirrhosis and portal hypertension. Of note, the autoimmune repertoire, which is established during the early stage of the disease process, can influence the clinical phenotype and the long-term prognosis of PBC. Because the natural course of PBC is being altered by treatment with ursodeoxycholic acid, the clinical significance of these PBC-specific autoantibodies awaits re-evaluation in various ethnicities." @default.
- W2076194704 created "2016-06-24" @default.
- W2076194704 creator A5030939408 @default.
- W2076194704 date "2014-07-24" @default.
- W2076194704 modified "2023-09-26" @default.
- W2076194704 title "Clinical Significance of Autoantibodies in Primary Biliary Cirrhosis" @default.
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- W2076194704 doi "https://doi.org/10.1055/s-0034-1383732" @default.
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