FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076196841> ?p ?o ?g. }

• W2076196841 endingPage "2270" @default.
• W2076196841 startingPage "2257" @default.
• W2076196841 abstract "Symptomatic infection with Neisseria gonorrhoeae (Gc) results in a potent polymorphonuclear leukocyte (PMN)-driven inflammatory response, but the mechanisms by which Gc withstands PMN attack are poorly defined. Here we report that Gc can suppress the PMN oxidative burst, a central component of the PMN antimicrobial arsenal. Primary human PMNs remained viable after exposure to liquid-grown, exponential-phase, opacity-associated protein (Opa)-negative Gc of strains FA1090 and MS11 but did not generate reactive oxygen species (ROS), even after bacterial opsonization. Liquid-grown FA1090 Gc expressing OpaB, an Opa protein previously correlated with PMN ROS production, elicited a minor PMN oxidative burst. PMN ROS production in response to Opa(-) and OpaB+ Gc was markedly enhanced if bacteria were agar-grown or if liquid-grown bacteria were heat-killed. Liquid-grown Opa(-) Gc inhibited the PMN oxidative burst elicited by isogenic dead bacteria, formylated peptides or Staphylococcus aureus but did not inhibit PMN ROS production by OpaB+ Gc or phorbol esters. Suppression of the oxidative burst required Gc-PMN contact and bacterial protein synthesis but not phagocytosis. These results suggest that viable Gc directly inhibits PMN signalling pathways required for induction of the oxidative burst, which may contribute to gonococcal pathogenesis during inflammatory stages of gonorrhoeal disease." @default.
• W2076196841 created "2016-06-24" @default.
• W2076196841 creator A5029543804 @default.
• W2076196841 creator A5080237857 @default.
• W2076196841 date "2008-11-01" @default.
• W2076196841 modified "2023-09-27" @default.
• W2076196841 title "<i>Neisseria gonorrhoeae</i>suppresses the oxidative burst of human polymorphonuclear leukocytes" @default.
• W2076196841 cites W1524005751 @default.
• W2076196841 cites W1539623201 @default.
• W2076196841 cites W1546761767 @default.
• W2076196841 cites W1553774013 @default.
• W2076196841 cites W1575925203 @default.
• W2076196841 cites W1594008356 @default.
• W2076196841 cites W1622088669 @default.
• W2076196841 cites W1661985738 @default.
• W2076196841 cites W1801867089 @default.
• W2076196841 cites W1836182851 @default.
• W2076196841 cites W1852598477 @default.
• W2076196841 cites W1854671426 @default.
• W2076196841 cites W1855843942 @default.
• W2076196841 cites W1862893351 @default.
• W2076196841 cites W1895845482 @default.
• W2076196841 cites W1903743075 @default.
• W2076196841 cites W1904133092 @default.
• W2076196841 cites W1907611525 @default.
• W2076196841 cites W1910966691 @default.
• W2076196841 cites W1933226978 @default.
• W2076196841 cites W1942012123 @default.
• W2076196841 cites W1965574502 @default.
• W2076196841 cites W1965908903 @default.
• W2076196841 cites W1970101706 @default.
• W2076196841 cites W1970727566 @default.
• W2076196841 cites W1983725736 @default.
• W2076196841 cites W1984465410 @default.
• W2076196841 cites W1988725767 @default.
• W2076196841 cites W1990949770 @default.
• W2076196841 cites W2000056524 @default.
• W2076196841 cites W2004679948 @default.
• W2076196841 cites W2008243630 @default.
• W2076196841 cites W2016355432 @default.
• W2076196841 cites W2023160761 @default.
• W2076196841 cites W2023822923 @default.
• W2076196841 cites W2028546667 @default.
• W2076196841 cites W2030101263 @default.
• W2076196841 cites W2031183059 @default.
• W2076196841 cites W2040626353 @default.
• W2076196841 cites W2055385251 @default.
• W2076196841 cites W2056171038 @default.
• W2076196841 cites W2058003632 @default.
• W2076196841 cites W2066515050 @default.
• W2076196841 cites W2069285405 @default.
• W2076196841 cites W2072018350 @default.
• W2076196841 cites W2079168625 @default.
• W2076196841 cites W2080974744 @default.
• W2076196841 cites W2095447604 @default.
• W2076196841 cites W2100305053 @default.
• W2076196841 cites W2101809821 @default.
• W2076196841 cites W2103812049 @default.
• W2076196841 cites W2107767157 @default.
• W2076196841 cites W2110526022 @default.
• W2076196841 cites W2111506134 @default.
• W2076196841 cites W2113556104 @default.
• W2076196841 cites W2118037244 @default.
• W2076196841 cites W2121865329 @default.
• W2076196841 cites W2122593087 @default.
• W2076196841 cites W2124930223 @default.
• W2076196841 cites W2125762027 @default.
• W2076196841 cites W2126103345 @default.
• W2076196841 cites W2131091712 @default.
• W2076196841 cites W2131648288 @default.
• W2076196841 cites W2132223529 @default.
• W2076196841 cites W2135490717 @default.
• W2076196841 cites W2137937616 @default.
• W2076196841 cites W2144379257 @default.
• W2076196841 cites W2150203465 @default.
• W2076196841 cites W2157078700 @default.
• W2076196841 cites W2160043086 @default.
• W2076196841 cites W2162041756 @default.
• W2076196841 cites W2164722793 @default.
• W2076196841 cites W2166745130 @default.
• W2076196841 cites W2320790849 @default.
• W2076196841 cites W4229630303 @default.
• W2076196841 cites W4230246066 @default.
• W2076196841 doi "https://doi.org/10.1111/j.1462-5822.2008.01205.x" @default.
• W2076196841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2692872" @default.
• W2076196841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18684112" @default.
• W2076196841 hasPublicationYear "2008" @default.
• W2076196841 type Work @default.
• W2076196841 sameAs 2076196841 @default.
• W2076196841 citedByCount "73" @default.
• W2076196841 countsByYear W20761968412012 @default.
• W2076196841 countsByYear W20761968412013 @default.
• W2076196841 countsByYear W20761968412014 @default.
• W2076196841 countsByYear W20761968412015 @default.
• W2076196841 countsByYear W20761968412016 @default.
• W2076196841 countsByYear W20761968412017 @default.
• W2076196841 countsByYear W20761968412018 @default.
• W2076196841 countsByYear W20761968412019 @default.

• next