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• W2076197476 abstract "The coupling between ATP hydrolysis and substrate transport remains a key question in the understanding of ABC-mediated transport. We show using the MalFGK2 complex reconstituted into nanodiscs, that membrane lipids participate directly to the coupling reaction by stabilizing the transporter in a low energy conformation. When surrounded by short acyl chain phospholipids, the transporter is unstable and hydrolyzes large amounts of ATP without inducing maltose. The presence of long acyl chain phospholipids stabilizes the conformational dynamics of the transporter, reduces its ATPase activity and restores dependence on maltose. Membrane lipids therefore play an essential allosteric function, they restrict the transporter ATPase activity to increase coupling to the substrate. In support to the notion, we show that increasing the conformational dynamics of MalFGK2 with mutations in MalF increases the transporter ATPase activity but decreases the maltose transport efficiency." @default.
• W2076197476 created "2016-06-24" @default.
• W2076197476 creator A5020096325 @default.
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• W2076197476 date "2013-08-01" @default.
• W2076197476 modified "2023-10-03" @default.
• W2076197476 title "The maltose ABC transporter: Action of membrane lipids on the transporter stability, coupling and ATPase activity" @default.
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• W2076197476 doi "https://doi.org/10.1016/j.bbamem.2013.03.024" @default.
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