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- W2076198632 abstract "Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families--the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses." @default.
- W2076198632 created "2016-06-24" @default.
- W2076198632 creator A5016005915 @default.
- W2076198632 creator A5054720102 @default.
- W2076198632 date "2012-12-14" @default.
- W2076198632 modified "2023-10-11" @default.
- W2076198632 title "The broad-spectrum antiviral functions of IFIT and IFITM proteins" @default.
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- W2076198632 doi "https://doi.org/10.1038/nri3344" @default.
- W2076198632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3773942" @default.
- W2076198632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23237964" @default.
- W2076198632 hasPublicationYear "2012" @default.
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