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- W2076198663 abstract "The redox-active protein cytochrome b562 has been engineered to introduce pairs of thiol groups in the form of cysteine residues at specified sites. Successful STM imaging of the molecules adsorbed on a gold surface indicated that one thiol group controls the orientation of the molecule and that the protein maintains its native form under the experimental conditions. Stable protein–gold STM tip electrical contact was directly observed to form via the second free thiol group in current–voltage and current–distance measurements. Proteins with thiol contacts positioned across the protein’s short axis displayed a conductance of (3.48 ± 0.05) × 10–5 G0. However proteins with thiol groups placed along the long axis reproducibly yielded two distinct values of (1.95 ± 0.03) × 10–5 G0 and (3.57 ± 0.11) × 10–5 G0, suggesting that the placement of the asymmetrically located haem within the protein influences electron transfer. In contrast, the unengineered wild-type cytochrome b562 had conductance values at least 1 order of magnitude less. Here we show that an electron transfer protein engineered to bind gold surfaces can be controllably oriented and electrically contacted to metallic electrodes, a prerequisite for potential integration into electronic circuits." @default.
- W2076198663 created "2016-06-24" @default.
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- W2076198663 date "2011-11-21" @default.
- W2076198663 modified "2023-10-18" @default.
- W2076198663 title "Orientation-Dependent Electron Transport in a Single Redox Protein" @default.
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- W2076198663 doi "https://doi.org/10.1021/nn2036818" @default.
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