FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076198744> ?p ?o ?g. }

• W2076198744 endingPage "127" @default.
• W2076198744 startingPage "117" @default.
• W2076198744 abstract "SPARC is a secreted glycoprotein that modulates cell shape and cell-matrix interactions. Levels of SPARC are increased at sites of somitogenesis, osteogenesis, and angiogenesis in the embryo and during wound repair in the adult. We have cloned and characterized SPARC from chicken embryo. A 2.2-kbp cDNA, obtained by a novel use of the polymerase chain reaction, was determined to encode a 298-residue protein that is 85% identical to human SPARC. Antigenic sites in particular appear to be highly conserved, as antibodies against C-terminal sequences of murine and bovine SPARC reacted with a 41–43 kDa protein in chicken embryo extracts. Chicken SPARC can be defined by four sequence signatures: (a) a conserved spacing of 11 cysteine residues in domain II, (b) the pentapeptide KKGHK in domain II, which is contained within a larger region of 31 identical residues, (c) a 100% conserved region of 10 residues in domain III, and (d) a C-terminal, calcium-binding EF-hand motif. SPARC mRNAs in the 10-day-old chicken embryo are represented by three sizes of 1.8, 2.2 and 3.0 kb. The relative steady-state levels for the 2.2-kb mRNA were determined as aorta ≥ skeletal muscle > calvarium > vertebra > anterior limb > kidney > heart > brain > skin and lung ≥ liver. The relative abundance of the 1.8-kb and 2.2-kb mRNAs varied among tissues and indicated that differential processing of SPARC mRNAs might occur. All three RNA species were detected by a cDNA probe for the N-terminal part of the coding region. Thus, the three mRNA species appear to arise from differential 3′ splicing and/or polyadenylation. Collective evidence demonstrates that SPARC has been well-conserved during vertebrate evolution, a finding that indicates a fundamental role for this protein in development." @default.
• W2076198744 created "2016-06-24" @default.
• W2076198744 creator A5002256474 @default.
• W2076198744 creator A5013087458 @default.
• W2076198744 creator A5031831236 @default.
• W2076198744 creator A5039961461 @default.
• W2076198744 creator A5088850502 @default.
• W2076198744 creator A5090527825 @default.
• W2076198744 date "1993-11-01" @default.
• W2076198744 modified "2023-10-17" @default.
• W2076198744 title "Molecular analysis of chicken embryo SPARC (osteonectin)" @default.
• W2076198744 cites W1121473917 @default.
• W2076198744 cites W1422803820 @default.
• W2076198744 cites W1481342123 @default.
• W2076198744 cites W1506676773 @default.
• W2076198744 cites W1524812740 @default.
• W2076198744 cites W1586178241 @default.
• W2076198744 cites W1605327673 @default.
• W2076198744 cites W1607767749 @default.
• W2076198744 cites W171910026 @default.
• W2076198744 cites W1964399899 @default.
• W2076198744 cites W1969019995 @default.
• W2076198744 cites W1973064020 @default.
• W2076198744 cites W1975304761 @default.
• W2076198744 cites W1982744124 @default.
• W2076198744 cites W1985629737 @default.
• W2076198744 cites W1988369735 @default.
• W2076198744 cites W1989859149 @default.
• W2076198744 cites W1991499181 @default.
• W2076198744 cites W1992829869 @default.
• W2076198744 cites W2002192621 @default.
• W2076198744 cites W2002285803 @default.
• W2076198744 cites W2003937770 @default.
• W2076198744 cites W2009310436 @default.
• W2076198744 cites W2014913262 @default.
• W2076198744 cites W2016417501 @default.
• W2076198744 cites W2024152221 @default.
• W2076198744 cites W2027204848 @default.
• W2076198744 cites W2027917774 @default.
• W2076198744 cites W2030145963 @default.
• W2076198744 cites W2033753997 @default.
• W2076198744 cites W2041918518 @default.
• W2076198744 cites W2053418558 @default.
• W2076198744 cites W2060285807 @default.
• W2076198744 cites W2060703962 @default.
• W2076198744 cites W2076364928 @default.
• W2076198744 cites W2077637821 @default.
• W2076198744 cites W2087381942 @default.
• W2076198744 cites W2088645577 @default.
• W2076198744 cites W2092341987 @default.
• W2076198744 cites W2095450147 @default.
• W2076198744 cites W2108736751 @default.
• W2076198744 cites W2133878295 @default.
• W2076198744 cites W2134812217 @default.
• W2076198744 cites W2140618470 @default.
• W2076198744 cites W2156899368 @default.
• W2076198744 cites W2165030170 @default.
• W2076198744 cites W2166931563 @default.
• W2076198744 cites W2326879084 @default.
• W2076198744 cites W2409910469 @default.
• W2076198744 cites W54857175 @default.
• W2076198744 doi "https://doi.org/10.1111/j.1432-1033.1993.tb18358.x" @default.
• W2076198744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7916692" @default.
• W2076198744 hasPublicationYear "1993" @default.
• W2076198744 type Work @default.
• W2076198744 sameAs 2076198744 @default.
• W2076198744 citedByCount "35" @default.
• W2076198744 countsByYear W20761987442014 @default.
• W2076198744 crossrefType "journal-article" @default.
• W2076198744 hasAuthorship W2076198744A5002256474 @default.
• W2076198744 hasAuthorship W2076198744A5013087458 @default.
• W2076198744 hasAuthorship W2076198744A5031831236 @default.
• W2076198744 hasAuthorship W2076198744A5039961461 @default.
• W2076198744 hasAuthorship W2076198744A5088850502 @default.
• W2076198744 hasAuthorship W2076198744A5090527825 @default.
• W2076198744 hasBestOaLocation W20761987442 @default.
• W2076198744 hasConcept C104317684 @default.
• W2076198744 hasConcept C105580179 @default.
• W2076198744 hasConcept C108625454 @default.
• W2076198744 hasConcept C131075544 @default.
• W2076198744 hasConcept C153911025 @default.
• W2076198744 hasConcept C160160445 @default.
• W2076198744 hasConcept C181199279 @default.
• W2076198744 hasConcept C187882448 @default.
• W2076198744 hasConcept C189482833 @default.
• W2076198744 hasConcept C196843134 @default.
• W2076198744 hasConcept C2781460891 @default.
• W2076198744 hasConcept C55493867 @default.
• W2076198744 hasConcept C86803240 @default.
• W2076198744 hasConcept C95444343 @default.
• W2076198744 hasConceptScore W2076198744C104317684 @default.
• W2076198744 hasConceptScore W2076198744C105580179 @default.
• W2076198744 hasConceptScore W2076198744C108625454 @default.
• W2076198744 hasConceptScore W2076198744C131075544 @default.
• W2076198744 hasConceptScore W2076198744C153911025 @default.
• W2076198744 hasConceptScore W2076198744C160160445 @default.
• W2076198744 hasConceptScore W2076198744C181199279 @default.
• W2076198744 hasConceptScore W2076198744C187882448 @default.

• next