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• W2076207624 abstract "OBJECTIVE: Ovarian stimulation with intrauterine insemination (IUI) forms the baseline treatment in couples with mild to moderate male factor and unexplained infertility. Several factors influence the effectiveness of IUI. Endometrial thickness and pattern have been implicated in the success of IUI, however there is limited data regarding gonadotropin cycles with IUI. The aim of this study was to investigate the role of endometrial pattern by ultrasound to the success of IUI with gonadotropins.DESIGN: Prospective analysis.MATERIALS AND METHODS: 532 cycles of 402 patients with unexplained and male infertility, having COH and IUI treatment from 2006 to 2007 were investigated. Patients were treated with 75 IU. rFSH (Gonal-F®; Serono, Turkey and Puregon®, Organon, Turkey) and ovarian response was assessed with TVU from day 8 of the cycles. A transvaginal ultrasound exam was performed on the day of hCG administration to measure endometrial thickness and endometrial echogenic pattern was also determined. IUI was performed 36 hours after hCG administration with a disposable IUI catheter. Echogenic pattern was designated as type A when there was trilaminar endometrium. Patients having trilaminar pattern with focal echogenicity was grouped as type B. Diffuse echogenicity has been grouped as type C pattern.RESULTS: Demographic data was found to be homogeneous between patients with ongoing pregnancy and nonpregnant patients except age, sperm motility before swim-up and sperm number after swim-up (Table 1). Endometrial thickness was not different between patients with ongoing pregnancy and nonpregnant patients. The lower limit of endometrial thickness that pregnancy achieved was 6 mm. Ongoing pregnancy rates were 15.9% and 25% in type A and B endometrial pattern respectively; however, there was no pregnancy in type C endometrial pattern and the difference was significant.CONCLUSIONS: Endometrial texture but not the endometrial thickness was associated with pregnancy outcome COH and IUI with gonadotropins. OBJECTIVE: Ovarian stimulation with intrauterine insemination (IUI) forms the baseline treatment in couples with mild to moderate male factor and unexplained infertility. Several factors influence the effectiveness of IUI. Endometrial thickness and pattern have been implicated in the success of IUI, however there is limited data regarding gonadotropin cycles with IUI. The aim of this study was to investigate the role of endometrial pattern by ultrasound to the success of IUI with gonadotropins. DESIGN: Prospective analysis. MATERIALS AND METHODS: 532 cycles of 402 patients with unexplained and male infertility, having COH and IUI treatment from 2006 to 2007 were investigated. Patients were treated with 75 IU. rFSH (Gonal-F®; Serono, Turkey and Puregon®, Organon, Turkey) and ovarian response was assessed with TVU from day 8 of the cycles. A transvaginal ultrasound exam was performed on the day of hCG administration to measure endometrial thickness and endometrial echogenic pattern was also determined. IUI was performed 36 hours after hCG administration with a disposable IUI catheter. Echogenic pattern was designated as type A when there was trilaminar endometrium. Patients having trilaminar pattern with focal echogenicity was grouped as type B. Diffuse echogenicity has been grouped as type C pattern. RESULTS: Demographic data was found to be homogeneous between patients with ongoing pregnancy and nonpregnant patients except age, sperm motility before swim-up and sperm number after swim-up (Table 1). Endometrial thickness was not different between patients with ongoing pregnancy and nonpregnant patients. The lower limit of endometrial thickness that pregnancy achieved was 6 mm. Ongoing pregnancy rates were 15.9% and 25% in type A and B endometrial pattern respectively; however, there was no pregnancy in type C endometrial pattern and the difference was significant. CONCLUSIONS: Endometrial texture but not the endometrial thickness was associated with pregnancy outcome COH and IUI with gonadotropins." @default.
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• W2076207624 date "2008-09-01" @default.
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• W2076207624 title "Endometrial thickness and texture as determinants of success in COH and IUI cycles with recombinant gonadotropins" @default.
• W2076207624 doi "https://doi.org/10.1016/j.fertnstert.2008.07.361" @default.
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