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• W2076215080 abstract "To test the hypothesis that there is a significant association between functionally relevant allelic variants of the monoamine oxidase A (MAO-A) polymorphism and sudden infant death syndrome (SIDS).In a case-control study of 142 cases of SIDS and 280 sex-matched control cases, the distribution of allelic and genotype variants of a promoter polymorphism of the MAO-A gene was examined using polymerase chain reaction locus amplification and fluorescence based fragment length analysis.There was a significantly differential distribution of allelic and genotype variants between females with SIDS and controls. Moreover, there was a significant association between SIDS in females and allelic and genotype variants, each related to a higher transcriptional activity at the MAO-A locus.Our results suggest a role of MAO-A in female SIDS pathogenesis exerted by functionally relevant allelic and genotype variants of the MAO-A polymorphism. However, with the complex and inconsistent evidence available to date, the impact of the MAO-A promoter polymorphism on SIDS etiology remains unclear." @default.
• W2076215080 created "2016-06-24" @default.
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• W2076215080 creator A5053554914 @default.
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• W2076215080 date "2013-07-01" @default.
• W2076215080 modified "2023-09-26" @default.
• W2076215080 title "Monoamine Oxidase A Gene Polymorphism and the Pathogenesis of Sudden Infant Death Syndrome" @default.
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• W2076215080 doi "https://doi.org/10.1016/j.jpeds.2012.12.072" @default.
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