FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076216973> ?p ?o ?g. }

• W2076216973 endingPage "32" @default.
• W2076216973 startingPage "26" @default.
• W2076216973 abstract "Pharmaceuticals discharged in municipal wastewater are of emerging concern because of their potential for inducing biological effects in aquatic organisms. Selective serotonin reuptake inhibitors (SSRIs), pharmaceuticals prescribed to treat chronic depression, have been detected in receiving and wastewaters. Fluoxetine is a highly prescribed model SSRI used to assess impacts of antidepressants on aquatic organisms. In this study, in vitro hepaticfluoxetine metabolism was determined in several model fish species: rainbow trout, goldfish, zebrafish and killifish. Incubation of fluoxetine with hepatic microsomes from trout pre-treated with carbamazepine showed a time-dependant loss of fluoxetine, concomitant with an increase in norfluoxetine, the major mammalian demethylated metabolite. However, fluoxetine was not well metabolized in reactions with hepatic microsomes from untreated fish. Fluoxetine loss was greater than norfluoxetine production, indicating that norfluoxetine is not the predominant fluoxetine biotransformation product in fish. Furthermore, norfluoxetine was often undetected, possibly indicating that fluoxetine demethylation is a minor metabolic pathway in fish. Inter-species differences in fluoxetine metabolism were not evident because of high intra-species variability, although killifish appeared to have the highest hepatic metabolic capacity for fluoxetine. Fluoxetine metabolism in mammals is catalyzed by cytochrome P450 (CYP) enzymes. Trout were exposed to knownCYP inducers, carbamazepine and 3-methylcholanthrene, to assess potential induction of hepatic fluoxetine metabolism. Microsomes from 3-methylcholanthrene treated fish did not induce detectable changes in fluoxetine concentrations in vitro, indicating that fish CYP1s are not involved in fluoxetine metabolism; the CYPs involved are still unclear. Identification of metabolites other than norfluoxetine warrants further investigation." @default.
• W2076216973 created "2016-06-24" @default.
• W2076216973 creator A5007769428 @default.
• W2076216973 creator A5007839244 @default.
• W2076216973 creator A5016758271 @default.
• W2076216973 creator A5066265469 @default.
• W2076216973 creator A5079316241 @default.
• W2076216973 date "2010-03-01" @default.
• W2076216973 modified "2023-09-27" @default.
• W2076216973 title "Cross-species comparison of fluoxetine metabolism with fish liver microsomes" @default.
• W2076216973 cites W1501688570 @default.
• W2076216973 cites W1964522544 @default.
• W2076216973 cites W1966325974 @default.
• W2076216973 cites W1976656763 @default.
• W2076216973 cites W1980086873 @default.
• W2076216973 cites W1984510403 @default.
• W2076216973 cites W1992568187 @default.
• W2076216973 cites W1999112484 @default.
• W2076216973 cites W2005331389 @default.
• W2076216973 cites W2011618884 @default.
• W2076216973 cites W2013241693 @default.
• W2076216973 cites W2014740010 @default.
• W2076216973 cites W2019793698 @default.
• W2076216973 cites W2024653634 @default.
• W2076216973 cites W2029308303 @default.
• W2076216973 cites W2031429717 @default.
• W2076216973 cites W2032724404 @default.
• W2076216973 cites W2033521032 @default.
• W2076216973 cites W2044911368 @default.
• W2076216973 cites W2045290351 @default.
• W2076216973 cites W2048349264 @default.
• W2076216973 cites W2048667544 @default.
• W2076216973 cites W2053322034 @default.
• W2076216973 cites W2058501351 @default.
• W2076216973 cites W2061936774 @default.
• W2076216973 cites W2062595049 @default.
• W2076216973 cites W2076912174 @default.
• W2076216973 cites W2090977130 @default.
• W2076216973 cites W2094482270 @default.
• W2076216973 cites W2116782015 @default.
• W2076216973 cites W2135990544 @default.
• W2076216973 cites W2150422808 @default.
• W2076216973 cites W2151552545 @default.
• W2076216973 cites W2151745588 @default.
• W2076216973 doi "https://doi.org/10.1016/j.chemosphere.2010.01.058" @default.
• W2076216973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20171714" @default.
• W2076216973 hasPublicationYear "2010" @default.
• W2076216973 type Work @default.
• W2076216973 sameAs 2076216973 @default.
• W2076216973 citedByCount "58" @default.
• W2076216973 countsByYear W20762169732012 @default.
• W2076216973 countsByYear W20762169732013 @default.
• W2076216973 countsByYear W20762169732014 @default.
• W2076216973 countsByYear W20762169732015 @default.
• W2076216973 countsByYear W20762169732016 @default.
• W2076216973 countsByYear W20762169732017 @default.
• W2076216973 countsByYear W20762169732018 @default.
• W2076216973 countsByYear W20762169732019 @default.
• W2076216973 countsByYear W20762169732020 @default.
• W2076216973 countsByYear W20762169732021 @default.
• W2076216973 countsByYear W20762169732022 @default.
• W2076216973 countsByYear W20762169732023 @default.
• W2076216973 crossrefType "journal-article" @default.
• W2076216973 hasAuthorship W2076216973A5007769428 @default.
• W2076216973 hasAuthorship W2076216973A5007839244 @default.
• W2076216973 hasAuthorship W2076216973A5016758271 @default.
• W2076216973 hasAuthorship W2076216973A5066265469 @default.
• W2076216973 hasAuthorship W2076216973A5079316241 @default.
• W2076216973 hasConcept C170493617 @default.
• W2076216973 hasConcept C181199279 @default.
• W2076216973 hasConcept C185592680 @default.
• W2076216973 hasConcept C2775864247 @default.
• W2076216973 hasConcept C2776134451 @default.
• W2076216973 hasConcept C2777477808 @default.
• W2076216973 hasConcept C2779153044 @default.
• W2076216973 hasConcept C2779363728 @default.
• W2076216973 hasConcept C2909208804 @default.
• W2076216973 hasConcept C505870484 @default.
• W2076216973 hasConcept C526171541 @default.
• W2076216973 hasConcept C55493867 @default.
• W2076216973 hasConcept C62231903 @default.
• W2076216973 hasConcept C86803240 @default.
• W2076216973 hasConcept C87644729 @default.
• W2076216973 hasConcept C98274493 @default.
• W2076216973 hasConceptScore W2076216973C170493617 @default.
• W2076216973 hasConceptScore W2076216973C181199279 @default.
• W2076216973 hasConceptScore W2076216973C185592680 @default.
• W2076216973 hasConceptScore W2076216973C2775864247 @default.
• W2076216973 hasConceptScore W2076216973C2776134451 @default.
• W2076216973 hasConceptScore W2076216973C2777477808 @default.
• W2076216973 hasConceptScore W2076216973C2779153044 @default.
• W2076216973 hasConceptScore W2076216973C2779363728 @default.
• W2076216973 hasConceptScore W2076216973C2909208804 @default.
• W2076216973 hasConceptScore W2076216973C505870484 @default.
• W2076216973 hasConceptScore W2076216973C526171541 @default.
• W2076216973 hasConceptScore W2076216973C55493867 @default.
• W2076216973 hasConceptScore W2076216973C62231903 @default.
• W2076216973 hasConceptScore W2076216973C86803240 @default.

• next