FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076220619> ?p ?o ?g. }

• W2076220619 endingPage "1248" @default.
• W2076220619 startingPage "1241" @default.
• W2076220619 abstract "Repeated intranasal infection of Balb/c mice with A/PR/8 influenza virus induced an intense antiviral IgG response dominated by the IgG2a subclass, and accompanied by the appearance of IgG2a reactive autoantibodies. Cells producing IgG2a reactive autoantibodies could then be cloned as hybridomas from the virus infected animals. Monoclonal antibodies produced by selected hybridomas U28, Z26 and Z41 produced IgM-type antibodies with strong specificity for the IgG2a isotype bearing a allotypic determinants on the Fc region. These IgG2a specific autoantibodies showed highly preferred binding to solid phase bound or aggregated IgG2a, compared to soluble native IgG2a. Based on these characteristics they were classified as mono-reactive rheumatoid factor (RF)-like autoantibodies. Passive administration of IgM type IgG2a-specific autoantibodies to influenza virus infected animals resulted in a long-term reduction in the secondary antiviral response. This could be demonstrated by decreased virus neutralizing activity of the serum and diminished level of IgG2a-type anti-viral antibodies. A similar effect was observed in Balb/c mice contact sensitized with oxazolone: passive administration of RF-like antibodies resulted in reduced IgG2a response to oxazolone while the level of antibodies belonging to other isotypes was not influenced. These results suggest an isotype-specific regulatory function of these RF-like autoantibodies presumably acting via antigen-antibody complexes." @default.
• W2076220619 created "2016-06-24" @default.
• W2076220619 creator A5001090870 @default.
• W2076220619 creator A5001819720 @default.
• W2076220619 creator A5022736513 @default.
• W2076220619 creator A5027516577 @default.
• W2076220619 creator A5044213235 @default.
• W2076220619 creator A5068945429 @default.
• W2076220619 date "1990-12-01" @default.
• W2076220619 modified "2023-10-18" @default.
• W2076220619 title "In vivo manipulation of IgG2a production by isotype-specific autoantibodies" @default.
• W2076220619 cites W1480103291 @default.
• W2076220619 cites W1494071868 @default.
• W2076220619 cites W1509021113 @default.
• W2076220619 cites W1557523926 @default.
• W2076220619 cites W1623439121 @default.
• W2076220619 cites W1682075913 @default.
• W2076220619 cites W193289982 @default.
• W2076220619 cites W1968125686 @default.
• W2076220619 cites W1969397646 @default.
• W2076220619 cites W1979986174 @default.
• W2076220619 cites W1990486482 @default.
• W2076220619 cites W1990964761 @default.
• W2076220619 cites W1992707199 @default.
• W2076220619 cites W2015931163 @default.
• W2076220619 cites W2021044670 @default.
• W2076220619 cites W2021916493 @default.
• W2076220619 cites W2023991938 @default.
• W2076220619 cites W2030522563 @default.
• W2076220619 cites W2032679326 @default.
• W2076220619 cites W2034515222 @default.
• W2076220619 cites W2044377326 @default.
• W2076220619 cites W2072889133 @default.
• W2076220619 cites W2095935128 @default.
• W2076220619 cites W2097386856 @default.
• W2076220619 cites W2127803671 @default.
• W2076220619 cites W2130923309 @default.
• W2076220619 cites W2138075969 @default.
• W2076220619 cites W2139605631 @default.
• W2076220619 cites W2139716890 @default.
• W2076220619 cites W2142373189 @default.
• W2076220619 cites W2143896178 @default.
• W2076220619 cites W2165371901 @default.
• W2076220619 cites W2397727489 @default.
• W2076220619 cites W25794465 @default.
• W2076220619 cites W1972857916 @default.
• W2076220619 cites W2267701288 @default.
• W2076220619 doi "https://doi.org/10.1016/0161-5890(90)90028-x" @default.
• W2076220619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2177147" @default.
• W2076220619 hasPublicationYear "1990" @default.
• W2076220619 type Work @default.
• W2076220619 sameAs 2076220619 @default.
• W2076220619 citedByCount "8" @default.
• W2076220619 crossrefType "journal-article" @default.
• W2076220619 hasAuthorship W2076220619A5001090870 @default.
• W2076220619 hasAuthorship W2076220619A5001819720 @default.
• W2076220619 hasAuthorship W2076220619A5022736513 @default.
• W2076220619 hasAuthorship W2076220619A5027516577 @default.
• W2076220619 hasAuthorship W2076220619A5044213235 @default.
• W2076220619 hasAuthorship W2076220619A5068945429 @default.
• W2076220619 hasConcept C147483822 @default.
• W2076220619 hasConcept C159047783 @default.
• W2076220619 hasConcept C159654299 @default.
• W2076220619 hasConcept C163764329 @default.
• W2076220619 hasConcept C185592680 @default.
• W2076220619 hasConcept C203014093 @default.
• W2076220619 hasConcept C2522874641 @default.
• W2076220619 hasConcept C2776194381 @default.
• W2076220619 hasConcept C2776232647 @default.
• W2076220619 hasConcept C2777991845 @default.
• W2076220619 hasConcept C2780898057 @default.
• W2076220619 hasConcept C542903549 @default.
• W2076220619 hasConcept C86803240 @default.
• W2076220619 hasConceptScore W2076220619C147483822 @default.
• W2076220619 hasConceptScore W2076220619C159047783 @default.
• W2076220619 hasConceptScore W2076220619C159654299 @default.
• W2076220619 hasConceptScore W2076220619C163764329 @default.
• W2076220619 hasConceptScore W2076220619C185592680 @default.
• W2076220619 hasConceptScore W2076220619C203014093 @default.
• W2076220619 hasConceptScore W2076220619C2522874641 @default.
• W2076220619 hasConceptScore W2076220619C2776194381 @default.
• W2076220619 hasConceptScore W2076220619C2776232647 @default.
• W2076220619 hasConceptScore W2076220619C2777991845 @default.
• W2076220619 hasConceptScore W2076220619C2780898057 @default.
• W2076220619 hasConceptScore W2076220619C542903549 @default.
• W2076220619 hasConceptScore W2076220619C86803240 @default.
• W2076220619 hasIssue "12" @default.
• W2076220619 hasLocation W20762206191 @default.
• W2076220619 hasLocation W20762206192 @default.
• W2076220619 hasOpenAccess W2076220619 @default.
• W2076220619 hasPrimaryLocation W20762206191 @default.
• W2076220619 hasRelatedWork W1993291539 @default.
• W2076220619 hasRelatedWork W2059678070 @default.
• W2076220619 hasRelatedWork W2066961297 @default.
• W2076220619 hasRelatedWork W2076220619 @default.
• W2076220619 hasRelatedWork W209105756 @default.
• W2076220619 hasRelatedWork W2099244599 @default.
• W2076220619 hasRelatedWork W2133024986 @default.

• next