Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076221453> ?p ?o ?g. }
- W2076221453 endingPage "169" @default.
- W2076221453 startingPage "155" @default.
- W2076221453 abstract "Postnatal development of the spinal cord serotonergic (5-HT) system and of swimming movements were studied in newborn Sprague-Dawley rats, in which the serotonin level in the central nervous system was lowered in the prenatal period. For this purpose, para-chlorophenylalanine (PCPA) (300 mg/kg) was administered intraperitoneally to pregnant mother rats on day 8 of gestation, followed by a daily injection of PCPA (80 mg/kg) from day 9 of gestation to delivery. The postnatal development of the 5-HT system in the spinal cord of the pups (PCPA-treated pups) born from the PCPA-administered mothers was markedly delayed during the period between PND 1 and PND 10 in comparison to that in the control pups born from healthy mothers. Postnatally, the control pups developed their swimming movements regularly through three distinct phases: forelimb dominant, forelimb and hindlimb well coordinated, hindlimb dominant. In contrast, in the PCPA-treated pups, swimming movements were disorganized during the period in which the development of 5-HT system was delayed. However, between PND 17 and 22 in which the 5-HT system developed to that extent observed in the control pups, the pups eventually developed swimming movements as observed in the control pups. These results suggest that the disorganized developmental process of swimming movements in the PCPA-treated pups is due to the possible failure in the prenatal and postnatal development of the 5-HT system and its target system in the brain stem and the spinal cord." @default.
- W2076221453 created "2016-06-24" @default.
- W2076221453 creator A5004559602 @default.
- W2076221453 creator A5044204717 @default.
- W2076221453 creator A5087085530 @default.
- W2076221453 date "1998-06-01" @default.
- W2076221453 modified "2023-10-06" @default.
- W2076221453 title "Prenatal administration of para-chlorophenylalanine results in suppression of serotonergic system and disturbance of swimming movements in newborn rats" @default.
- W2076221453 cites W1577210222 @default.
- W2076221453 cites W1608846710 @default.
- W2076221453 cites W1618896030 @default.
- W2076221453 cites W1973002494 @default.
- W2076221453 cites W1977969437 @default.
- W2076221453 cites W1982508615 @default.
- W2076221453 cites W1985057945 @default.
- W2076221453 cites W1987243932 @default.
- W2076221453 cites W2003138967 @default.
- W2076221453 cites W2004106188 @default.
- W2076221453 cites W2005333955 @default.
- W2076221453 cites W2011681818 @default.
- W2076221453 cites W2016411315 @default.
- W2076221453 cites W2020460680 @default.
- W2076221453 cites W2022698325 @default.
- W2076221453 cites W2023673457 @default.
- W2076221453 cites W2026223149 @default.
- W2076221453 cites W2031565323 @default.
- W2076221453 cites W2032644802 @default.
- W2076221453 cites W2036386442 @default.
- W2076221453 cites W2038174426 @default.
- W2076221453 cites W2044935982 @default.
- W2076221453 cites W2049735743 @default.
- W2076221453 cites W2061296589 @default.
- W2076221453 cites W2065754197 @default.
- W2076221453 cites W2071810655 @default.
- W2076221453 cites W2075769200 @default.
- W2076221453 cites W2078347996 @default.
- W2076221453 cites W2078450592 @default.
- W2076221453 cites W2079587963 @default.
- W2076221453 cites W2089182814 @default.
- W2076221453 cites W2094137255 @default.
- W2076221453 cites W2095056643 @default.
- W2076221453 cites W2127939929 @default.
- W2076221453 cites W2146277962 @default.
- W2076221453 cites W2398843823 @default.
- W2076221453 cites W2472674933 @default.
- W2076221453 cites W2886747681 @default.
- W2076221453 cites W4247067925 @default.
- W2076221453 cites W2034205644 @default.
- W2076221453 doi "https://doi.org/10.1016/s0168-0102(98)00034-0" @default.
- W2076221453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9700721" @default.
- W2076221453 hasPublicationYear "1998" @default.
- W2076221453 type Work @default.
- W2076221453 sameAs 2076221453 @default.
- W2076221453 citedByCount "25" @default.
- W2076221453 countsByYear W20762214532012 @default.
- W2076221453 countsByYear W20762214532014 @default.
- W2076221453 countsByYear W20762214532020 @default.
- W2076221453 countsByYear W20762214532022 @default.
- W2076221453 crossrefType "journal-article" @default.
- W2076221453 hasAuthorship W2076221453A5004559602 @default.
- W2076221453 hasAuthorship W2076221453A5044204717 @default.
- W2076221453 hasAuthorship W2076221453A5087085530 @default.
- W2076221453 hasConcept C105702510 @default.
- W2076221453 hasConcept C118552586 @default.
- W2076221453 hasConcept C126322002 @default.
- W2076221453 hasConcept C134018914 @default.
- W2076221453 hasConcept C170493617 @default.
- W2076221453 hasConcept C2775864247 @default.
- W2076221453 hasConcept C2778646069 @default.
- W2076221453 hasConcept C2779234561 @default.
- W2076221453 hasConcept C2780775167 @default.
- W2076221453 hasConcept C37000724 @default.
- W2076221453 hasConcept C46973012 @default.
- W2076221453 hasConcept C51738704 @default.
- W2076221453 hasConcept C529278444 @default.
- W2076221453 hasConcept C54355233 @default.
- W2076221453 hasConcept C71924100 @default.
- W2076221453 hasConcept C86803240 @default.
- W2076221453 hasConceptScore W2076221453C105702510 @default.
- W2076221453 hasConceptScore W2076221453C118552586 @default.
- W2076221453 hasConceptScore W2076221453C126322002 @default.
- W2076221453 hasConceptScore W2076221453C134018914 @default.
- W2076221453 hasConceptScore W2076221453C170493617 @default.
- W2076221453 hasConceptScore W2076221453C2775864247 @default.
- W2076221453 hasConceptScore W2076221453C2778646069 @default.
- W2076221453 hasConceptScore W2076221453C2779234561 @default.
- W2076221453 hasConceptScore W2076221453C2780775167 @default.
- W2076221453 hasConceptScore W2076221453C37000724 @default.
- W2076221453 hasConceptScore W2076221453C46973012 @default.
- W2076221453 hasConceptScore W2076221453C51738704 @default.
- W2076221453 hasConceptScore W2076221453C529278444 @default.
- W2076221453 hasConceptScore W2076221453C54355233 @default.
- W2076221453 hasConceptScore W2076221453C71924100 @default.
- W2076221453 hasConceptScore W2076221453C86803240 @default.
- W2076221453 hasFunder F4320320912 @default.
- W2076221453 hasIssue "2" @default.
- W2076221453 hasLocation W20762214531 @default.
- W2076221453 hasLocation W20762214532 @default.