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- W2076222040 abstract "Les auteurs évaluent l'apport d'une chronothérapie comportant du 5-fluoro-uracile (5-FU), de l'acide folinique et du carboplatine (en infusion ambulatoire par pompe chronomodulable 5/21 jours) au traitement de patients souffrant d'un cancer de l'œsophage (52 cas) ou de l'estomac (56 cas) essentiellement de stade avancé. La tolérance au traitement fut très favorable (grades 3–4, pourcentage de patients : mucite 11–23 % ; leucocytes 6–19 % ; plaquettes 18–50 % ; pas de troubles digestifs ni d'alopécie). L'évolution tumorale fut aussi intéressante avec des taux de réponses majeures de 61 % (estomacs métastatiques) à 79 % (œsophages). La survie modeste dans les cancers de l'œsophage (médiane : 9,2 mois) fut plus favorable dans les cancers de l'estomac (médiane dans les cas disséminés : 12,7 mois ; 72 % survivants à cinq ans dans les cas traités après chirurgie curative). The authors evaluated the impact of a chronotherapy with 5-FU, folinic acid and carboplatine (chronomodulated infusions by ambulatory pumps; 5/21 days) for the management of oesophagus (52 cases) and gastric (56 cases) cancer patients. The overall tolerance of treatment was gauged excellent (grade 3–4; % patients: mucitis: 11–23%; leucopenia 6–19% ; thrombopenia 18–50%; almost no digestive disturbances nor alopecia). Also tumor outcome was considered interesting with major responses rate in 61% (gastric) to 79% (oesophagus) of patients. The median survival of oesophageal cancer was limited to 9.2 months; the one of disseminated gastric cancer was 12.7 months but 72% of curatively resected patients were alive at 5 + years." @default.
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- W2076222040 date "2007-04-01" @default.
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- W2076222040 title "Intérêt de la chronothérapie dans le traitement pluridisciplinaire des cancers de l'œsophage et de l'estomac" @default.
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- W2076222040 doi "https://doi.org/10.1016/j.patbio.2006.12.002" @default.
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