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- W2076222045 abstract "1 Apomorphine and oxotremorine caused a dose-related fall in core temperature in the mouse and a fall in core temperature preceded by an increase in tail-skin temperature in the rat. 2 In both species the slope of the dose-response curve was greater for oxotremorine (8.2 ± 0.6 mice, 0.9 ± 0.1 rats) than it was for apomorphine (1.7 ± 0.3 mice, 0.5 ± 0.07 rats). 3 The mouse was more sensitive than the rat to the effects of both agonists. 4 Atropine (0.625 to 5 mg/kg) and hyoscine (0.5 and 1 mg/kg) caused a dose-related rightward shift of the dose-response curve to oxotremorine in mice, but pimozide (0.25 to 1 mg/kg) was ineffective. Similar results were obtained in the rat. 5 Pimozide (0.125 to 1 mg/kg) caused a dose-related rightward shift of the dose-response curve to apomorphine in mice, but atropine (1.25 to 1 mg/kg) and hyoscine (0.5 and 1 mg/kg) were ineffective. Similar results were obtained in the rat. 6 Intrahypothalamic injection of apomorphine (10 μg) and oxotremorine (1.25 μg) caused a fall in core temperature in rats. Pimozide (0.5 mg/kg i.p.) caused reversal of the effect of apomorphine but did not significantly change the response to oxotremorine. Atropine (2.5 mg/kg i.p.) blocked the effect of oxotremorine, but not that of apomorphine. 7 These results suggest that there are both central dopamine and central muscarinic acetylcholine receptors which mediate a fall in core temperature in rodents, but do not support the hypothesis that any connection exists between these two receptor populations." @default.
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- W2076222045 date "1978-03-01" @default.
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- W2076222045 title "IS ACETYLCHOLINE INVOLVED IN A DOPAMINE RECEPTOR MEDIATED HYPOTHERMIA IN MICE AND RATS?" @default.
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- W2076222045 doi "https://doi.org/10.1111/j.1476-5381.1978.tb08466.x" @default.
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