Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076223532> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2076223532 endingPage "1438" @default.
- W2076223532 startingPage "1434" @default.
- W2076223532 abstract "Cryptococcus neoformans infections are a major cause of morbidity and mortality for HIV-infected persons. Containment of the initial respiratory inoculation to the lung appears defective in patients with AIDS despite the low burden of HIV in bronchoalveolar macrophages. We have studied the fungistatic activity of human bronchoalveolar macrophages (BAM) cultured with an encapsulated strain of C. neoformans in the presence of pooled human serum. We observed 51.6% fungistasis after 24 h of culture. Fungistasis was diminished if the pooled human serum was heat-inactivated but was not affected by anticryptococcal capsular IgG. HIV envelope protein (gp120) has been shown to interfere with lymphocyte activation in vitro. We studied the effects of gp120 on BAM function and found that fungistatic activity was inhibited 25% (p < 0.001). Although binding of yeasts was not affected, gp120 inhibited the internalization of bound yeasts by 46% (p = 0.025). These experiments indicate that gp120 decreases the internalization and fungistasis of C. neoformans by human BAM, and they suggest a mechanism to explain how a small number of HIV-1-infected cells in the lung could impair the containment of C. neoformans." @default.
- W2076223532 created "2016-06-24" @default.
- W2076223532 creator A5030705731 @default.
- W2076223532 creator A5040120344 @default.
- W2076223532 creator A5054141043 @default.
- W2076223532 creator A5074656984 @default.
- W2076223532 date "1992-12-01" @default.
- W2076223532 modified "2023-10-14" @default.
- W2076223532 title "HIV-1 Envelope Protein (gp120) Inhibits the Activity of Human Bronchoalveolar Macrophages against<i>Cryptococcus neoformans</i>" @default.
- W2076223532 cites W1516578436 @default.
- W2076223532 cites W1976838955 @default.
- W2076223532 cites W2066121768 @default.
- W2076223532 cites W2105236799 @default.
- W2076223532 cites W2111189608 @default.
- W2076223532 cites W4255745456 @default.
- W2076223532 cites W99188018 @default.
- W2076223532 doi "https://doi.org/10.1164/ajrccm/146.6.1434" @default.
- W2076223532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1456558" @default.
- W2076223532 hasPublicationYear "1992" @default.
- W2076223532 type Work @default.
- W2076223532 sameAs 2076223532 @default.
- W2076223532 citedByCount "35" @default.
- W2076223532 countsByYear W20762235322014 @default.
- W2076223532 countsByYear W20762235322021 @default.
- W2076223532 countsByYear W20762235322023 @default.
- W2076223532 crossrefType "journal-article" @default.
- W2076223532 hasAuthorship W2076223532A5030705731 @default.
- W2076223532 hasAuthorship W2076223532A5040120344 @default.
- W2076223532 hasAuthorship W2076223532A5054141043 @default.
- W2076223532 hasAuthorship W2076223532A5074656984 @default.
- W2076223532 hasConcept C126322002 @default.
- W2076223532 hasConcept C139770010 @default.
- W2076223532 hasConcept C1491633281 @default.
- W2076223532 hasConcept C159047783 @default.
- W2076223532 hasConcept C159654299 @default.
- W2076223532 hasConcept C202751555 @default.
- W2076223532 hasConcept C203014093 @default.
- W2076223532 hasConcept C2777714996 @default.
- W2076223532 hasConcept C2777761686 @default.
- W2076223532 hasConcept C2777893358 @default.
- W2076223532 hasConcept C2777961210 @default.
- W2076223532 hasConcept C2779413141 @default.
- W2076223532 hasConcept C55493867 @default.
- W2076223532 hasConcept C71924100 @default.
- W2076223532 hasConcept C86803240 @default.
- W2076223532 hasConcept C89423630 @default.
- W2076223532 hasConceptScore W2076223532C126322002 @default.
- W2076223532 hasConceptScore W2076223532C139770010 @default.
- W2076223532 hasConceptScore W2076223532C1491633281 @default.
- W2076223532 hasConceptScore W2076223532C159047783 @default.
- W2076223532 hasConceptScore W2076223532C159654299 @default.
- W2076223532 hasConceptScore W2076223532C202751555 @default.
- W2076223532 hasConceptScore W2076223532C203014093 @default.
- W2076223532 hasConceptScore W2076223532C2777714996 @default.
- W2076223532 hasConceptScore W2076223532C2777761686 @default.
- W2076223532 hasConceptScore W2076223532C2777893358 @default.
- W2076223532 hasConceptScore W2076223532C2777961210 @default.
- W2076223532 hasConceptScore W2076223532C2779413141 @default.
- W2076223532 hasConceptScore W2076223532C55493867 @default.
- W2076223532 hasConceptScore W2076223532C71924100 @default.
- W2076223532 hasConceptScore W2076223532C86803240 @default.
- W2076223532 hasConceptScore W2076223532C89423630 @default.
- W2076223532 hasIssue "6" @default.
- W2076223532 hasLocation W20762235321 @default.
- W2076223532 hasLocation W20762235322 @default.
- W2076223532 hasOpenAccess W2076223532 @default.
- W2076223532 hasPrimaryLocation W20762235321 @default.
- W2076223532 hasRelatedWork W1817460788 @default.
- W2076223532 hasRelatedWork W1859247973 @default.
- W2076223532 hasRelatedWork W1959967360 @default.
- W2076223532 hasRelatedWork W1993414228 @default.
- W2076223532 hasRelatedWork W2075887210 @default.
- W2076223532 hasRelatedWork W2114534320 @default.
- W2076223532 hasRelatedWork W2139873095 @default.
- W2076223532 hasRelatedWork W2313503697 @default.
- W2076223532 hasRelatedWork W2609326071 @default.
- W2076223532 hasRelatedWork W4210980776 @default.
- W2076223532 hasVolume "146" @default.
- W2076223532 isParatext "false" @default.
- W2076223532 isRetracted "false" @default.
- W2076223532 magId "2076223532" @default.
- W2076223532 workType "article" @default.