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• W2076223841 abstract "The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as “Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).” Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD–MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD–MBD. The kidney plays an important role in the regulation of mineral metabolism. As kidney function declines, there is a progressive deterioration in mineral homeostasis, along with various abnormalities, including bone disease and vascular calcification, which has recently been named as “Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD).” Although the precise mechanisms of this systemic disorder remain to be elucidated, accumulating evidence suggest that uremic toxins contribute substantially to the development of CKD–MBD, partly through evoking oxidative stress in the bone and cardiovascular systems. This brief review summarizes recent work on the role of uremic toxins and oxidative stress in the development of CKD–MBD." @default.
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• W2076223841 date "2012-01-01" @default.
• W2076223841 modified "2023-10-18" @default.
• W2076223841 title "Role of Uremic Toxins and Oxidative Stress in the Development of Chronic Kidney Disease–Mineral and Bone Disorder" @default.
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• W2076223841 doi "https://doi.org/10.1053/j.jrn.2011.10.031" @default.
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