Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076224320> ?p ?o ?g. }
- W2076224320 endingPage "921" @default.
- W2076224320 startingPage "915" @default.
- W2076224320 abstract "Multiple myeloma is a late stage B-cell malignancy that is characterized by recurrent translocations into the immunoglobulin heavy chain locus as well as multiple and complex chromosomal abnormalities. Multiple myeloma is not characterized by a defining IgH translocation partner locus; rather, the frequency of individual translocations ranges from 5% to 15% of the patient population. The current hypothesis that IgH translocations contribute to chromosomal instability through the augmented expression of cyclin D family members and upstream regulatory gene products has led to the development of clinical therapies targeting these potentially oncogenic gene products. Here, we postulate that IgH translocations affect both cyclin D family members and spindle assembly pathways. In forming the hypothesis, this manuscript provides a mechanistic connectivity between IgH translocations and associated chromosome 13 deletions and highlights a number of additional gene products that, along with already defined target genes, may be deregulated in myeloma and represent potential therapeutic targets." @default.
- W2076224320 created "2016-06-24" @default.
- W2076224320 creator A5058042409 @default.
- W2076224320 creator A5058237113 @default.
- W2076224320 date "2005-01-01" @default.
- W2076224320 modified "2023-09-25" @default.
- W2076224320 title "A potential role for centrosomal deregulation within IgH translocation-positive myeloma" @default.
- W2076224320 cites W1569755992 @default.
- W2076224320 cites W1657157395 @default.
- W2076224320 cites W1963759286 @default.
- W2076224320 cites W1964212058 @default.
- W2076224320 cites W1964253746 @default.
- W2076224320 cites W1965067010 @default.
- W2076224320 cites W1977409409 @default.
- W2076224320 cites W1978732654 @default.
- W2076224320 cites W1980709350 @default.
- W2076224320 cites W1984534203 @default.
- W2076224320 cites W1985431969 @default.
- W2076224320 cites W1987386926 @default.
- W2076224320 cites W1988686682 @default.
- W2076224320 cites W1990317973 @default.
- W2076224320 cites W2004321494 @default.
- W2076224320 cites W2006351736 @default.
- W2076224320 cites W2007384310 @default.
- W2076224320 cites W2008609502 @default.
- W2076224320 cites W2014089652 @default.
- W2076224320 cites W2014620140 @default.
- W2076224320 cites W2022848869 @default.
- W2076224320 cites W2025829112 @default.
- W2076224320 cites W2034438569 @default.
- W2076224320 cites W2035309762 @default.
- W2076224320 cites W2053442775 @default.
- W2076224320 cites W2053456304 @default.
- W2076224320 cites W2053535892 @default.
- W2076224320 cites W2063827408 @default.
- W2076224320 cites W2065975880 @default.
- W2076224320 cites W2068809534 @default.
- W2076224320 cites W2075175917 @default.
- W2076224320 cites W2077965268 @default.
- W2076224320 cites W2089063008 @default.
- W2076224320 cites W2089596886 @default.
- W2076224320 cites W2103114868 @default.
- W2076224320 cites W2126116268 @default.
- W2076224320 cites W2130725713 @default.
- W2076224320 cites W2138180163 @default.
- W2076224320 cites W2145807414 @default.
- W2076224320 cites W2151911073 @default.
- W2076224320 cites W2152557467 @default.
- W2076224320 cites W2154492966 @default.
- W2076224320 cites W2155820436 @default.
- W2076224320 cites W2158232840 @default.
- W2076224320 cites W2160300160 @default.
- W2076224320 cites W2166508172 @default.
- W2076224320 cites W4211143050 @default.
- W2076224320 cites W4212909492 @default.
- W2076224320 cites W4239601631 @default.
- W2076224320 doi "https://doi.org/10.1016/j.mehy.2005.05.031" @default.
- W2076224320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16023302" @default.
- W2076224320 hasPublicationYear "2005" @default.
- W2076224320 type Work @default.
- W2076224320 sameAs 2076224320 @default.
- W2076224320 citedByCount "3" @default.
- W2076224320 countsByYear W20762243202012 @default.
- W2076224320 countsByYear W20762243202020 @default.
- W2076224320 crossrefType "journal-article" @default.
- W2076224320 hasAuthorship W2076224320A5058042409 @default.
- W2076224320 hasAuthorship W2076224320A5058237113 @default.
- W2076224320 hasConcept C104317684 @default.
- W2076224320 hasConcept C138626823 @default.
- W2076224320 hasConcept C203014093 @default.
- W2076224320 hasConcept C2776364478 @default.
- W2076224320 hasConcept C502942594 @default.
- W2076224320 hasConcept C54355233 @default.
- W2076224320 hasConcept C86803240 @default.
- W2076224320 hasConceptScore W2076224320C104317684 @default.
- W2076224320 hasConceptScore W2076224320C138626823 @default.
- W2076224320 hasConceptScore W2076224320C203014093 @default.
- W2076224320 hasConceptScore W2076224320C2776364478 @default.
- W2076224320 hasConceptScore W2076224320C502942594 @default.
- W2076224320 hasConceptScore W2076224320C54355233 @default.
- W2076224320 hasConceptScore W2076224320C86803240 @default.
- W2076224320 hasIssue "5" @default.
- W2076224320 hasLocation W20762243201 @default.
- W2076224320 hasLocation W20762243202 @default.
- W2076224320 hasOpenAccess W2076224320 @default.
- W2076224320 hasPrimaryLocation W20762243201 @default.
- W2076224320 hasRelatedWork W1941502008 @default.
- W2076224320 hasRelatedWork W1984590050 @default.
- W2076224320 hasRelatedWork W1991523530 @default.
- W2076224320 hasRelatedWork W2002128513 @default.
- W2076224320 hasRelatedWork W2020824267 @default.
- W2076224320 hasRelatedWork W2021040442 @default.
- W2076224320 hasRelatedWork W2171277769 @default.
- W2076224320 hasRelatedWork W2505699891 @default.
- W2076224320 hasRelatedWork W2612577867 @default.
- W2076224320 hasRelatedWork W2092874662 @default.
- W2076224320 hasVolume "65" @default.
- W2076224320 isParatext "false" @default.