Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076226152> ?p ?o ?g. }
- W2076226152 endingPage "87" @default.
- W2076226152 startingPage "74" @default.
- W2076226152 abstract "Permeabilization of the outer mitochondrial membrane that leads to the release of cytochrome c and several other apoptogenic proteins from mitochondria into cytosol represents a commitment point of apoptotic pathway in mammalian cells. This crucial event is governed by proteins of the Bcl-2 family. Molecular mechanisms, by which Bcl-2 family proteins permeabilize mitochondrial membrane, remain under dispute. Although yeast does not have apparent homologues of these proteins, when mammalian members of Bcl-2 family are expressed in yeast, they retain their activity, making yeast an attractive model system, in which to study their action. This review focuses on using yeast expressing mammalian proteins of the Bcl-2 family as a tool to investigate mechanisms, by which these proteins permeabilize mitochondrial membranes, mechanisms, by which pro- and antiapoptotic members of this family interact, and involvement of other cellular components in the regulation of programmed cell death by Bcl-2 family proteins." @default.
- W2076226152 created "2016-06-24" @default.
- W2076226152 creator A5006611804 @default.
- W2076226152 creator A5008043208 @default.
- W2076226152 creator A5046792744 @default.
- W2076226152 date "2015-03-02" @default.
- W2076226152 modified "2023-09-27" @default.
- W2076226152 title "Yeast as a tool for studying proteins of the Bcl-2 family" @default.
- W2076226152 cites W1506214749 @default.
- W2076226152 cites W1528360418 @default.
- W2076226152 cites W1566777539 @default.
- W2076226152 cites W1595435854 @default.
- W2076226152 cites W1644794975 @default.
- W2076226152 cites W1866197725 @default.
- W2076226152 cites W1965217295 @default.
- W2076226152 cites W1966793349 @default.
- W2076226152 cites W1968488436 @default.
- W2076226152 cites W1970329726 @default.
- W2076226152 cites W1971608015 @default.
- W2076226152 cites W1971626647 @default.
- W2076226152 cites W1977258127 @default.
- W2076226152 cites W1980345051 @default.
- W2076226152 cites W1981166298 @default.
- W2076226152 cites W1981732015 @default.
- W2076226152 cites W1982603939 @default.
- W2076226152 cites W1984498109 @default.
- W2076226152 cites W1985773900 @default.
- W2076226152 cites W1985879199 @default.
- W2076226152 cites W1987024939 @default.
- W2076226152 cites W1987806865 @default.
- W2076226152 cites W1988178204 @default.
- W2076226152 cites W1990697320 @default.
- W2076226152 cites W1993059855 @default.
- W2076226152 cites W1993552956 @default.
- W2076226152 cites W1994446224 @default.
- W2076226152 cites W1994568480 @default.
- W2076226152 cites W1995354282 @default.
- W2076226152 cites W1997127808 @default.
- W2076226152 cites W2002311094 @default.
- W2076226152 cites W2002973070 @default.
- W2076226152 cites W2004169723 @default.
- W2076226152 cites W2008715871 @default.
- W2076226152 cites W2009424100 @default.
- W2076226152 cites W2011797287 @default.
- W2076226152 cites W2012974735 @default.
- W2076226152 cites W2013091489 @default.
- W2076226152 cites W2014294890 @default.
- W2076226152 cites W2014335323 @default.
- W2076226152 cites W2018439544 @default.
- W2076226152 cites W2019572526 @default.
- W2076226152 cites W2020933791 @default.
- W2076226152 cites W2023144237 @default.
- W2076226152 cites W2024996523 @default.
- W2076226152 cites W2025404996 @default.
- W2076226152 cites W2025426978 @default.
- W2076226152 cites W2025897016 @default.
- W2076226152 cites W2029987427 @default.
- W2076226152 cites W2031079887 @default.
- W2076226152 cites W2031315018 @default.
- W2076226152 cites W2031360193 @default.
- W2076226152 cites W2033847504 @default.
- W2076226152 cites W2036222374 @default.
- W2076226152 cites W2036413220 @default.
- W2076226152 cites W2037500108 @default.
- W2076226152 cites W2041459355 @default.
- W2076226152 cites W2042611670 @default.
- W2076226152 cites W2045226993 @default.
- W2076226152 cites W2047015858 @default.
- W2076226152 cites W2047058597 @default.
- W2076226152 cites W2047800998 @default.
- W2076226152 cites W2050207302 @default.
- W2076226152 cites W2050374206 @default.
- W2076226152 cites W2051219590 @default.
- W2076226152 cites W2059993219 @default.
- W2076226152 cites W2060715424 @default.
- W2076226152 cites W2060893047 @default.
- W2076226152 cites W2063099262 @default.
- W2076226152 cites W2063362926 @default.
- W2076226152 cites W2068966845 @default.
- W2076226152 cites W2069129416 @default.
- W2076226152 cites W2071530913 @default.
- W2076226152 cites W2072424483 @default.
- W2076226152 cites W2075757507 @default.
- W2076226152 cites W2079513929 @default.
- W2076226152 cites W2085419794 @default.
- W2076226152 cites W2085728531 @default.
- W2076226152 cites W2085943276 @default.
- W2076226152 cites W2086090484 @default.
- W2076226152 cites W2086623904 @default.
- W2076226152 cites W2087174680 @default.
- W2076226152 cites W2088344435 @default.
- W2076226152 cites W2088629175 @default.
- W2076226152 cites W2092514471 @default.
- W2076226152 cites W2093628776 @default.
- W2076226152 cites W2093999644 @default.
- W2076226152 cites W2095122505 @default.
- W2076226152 cites W2096007038 @default.
- W2076226152 cites W2098210382 @default.