Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076229035> ?p ?o ?g. }
- W2076229035 endingPage "168" @default.
- W2076229035 startingPage "161" @default.
- W2076229035 abstract "Tryptophan metabolism, through the kynurenine pathway, produces neurotoxic intermediates that are implicated in the pathogenesis of Alzheimer's disease. In particular, oxidative stress via 3-hydroxykynurenine (3-HK) and its cleaved product 3-hydroxyanthranilic acid (3-HAA) significantly damages neuronal tissue and may potentially contribute to a cycle of neurodegeneration through consequent amyloid-β accumulation, glial activation, and up-regulation of the kynurenine pathway. To determine the role of the kynurenine pathway in eliciting and continuing oxidative stress within Alzheimer's diseased brains, we used immunocytochemical methods to show elevated levels of 3-HK modifications and the upstream, rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO-1) in Alzheimer's diseased brains when compared to controls. Importantly, the association of IDO-1 with senile plaques was confirmed and, for the first time, IDO-1 was shown to be specifically localized in conjunction with neurofibrillary tangles. As senile plaques and neurofibrillary tangles are the pathological hallmarks of Alzheimer's disease, our study provides further evidence that the kynurenine pathway is involved with the destructive neurodegenerative pathway of Alzheimer's disease." @default.
- W2076229035 created "2016-06-24" @default.
- W2076229035 creator A5001501102 @default.
- W2076229035 creator A5002609147 @default.
- W2076229035 creator A5012826249 @default.
- W2076229035 creator A5021420538 @default.
- W2076229035 creator A5026442699 @default.
- W2076229035 creator A5029520152 @default.
- W2076229035 creator A5041697861 @default.
- W2076229035 creator A5061884568 @default.
- W2076229035 creator A5064238762 @default.
- W2076229035 creator A5071772212 @default.
- W2076229035 creator A5075477128 @default.
- W2076229035 creator A5076574305 @default.
- W2076229035 date "2010-08-01" @default.
- W2076229035 modified "2023-10-11" @default.
- W2076229035 title "Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease" @default.
- W2076229035 cites W114145985 @default.
- W2076229035 cites W1495741014 @default.
- W2076229035 cites W1542215809 @default.
- W2076229035 cites W1547937746 @default.
- W2076229035 cites W1597763516 @default.
- W2076229035 cites W1600169467 @default.
- W2076229035 cites W1662308449 @default.
- W2076229035 cites W1727403723 @default.
- W2076229035 cites W1834981029 @default.
- W2076229035 cites W1976625832 @default.
- W2076229035 cites W1977011271 @default.
- W2076229035 cites W1984369710 @default.
- W2076229035 cites W1984938699 @default.
- W2076229035 cites W1988691690 @default.
- W2076229035 cites W1996006408 @default.
- W2076229035 cites W1997863414 @default.
- W2076229035 cites W1998863012 @default.
- W2076229035 cites W2000183088 @default.
- W2076229035 cites W2000762235 @default.
- W2076229035 cites W2004212414 @default.
- W2076229035 cites W2016841149 @default.
- W2076229035 cites W2018333394 @default.
- W2076229035 cites W2020172011 @default.
- W2076229035 cites W2022499907 @default.
- W2076229035 cites W2028303382 @default.
- W2076229035 cites W2033447168 @default.
- W2076229035 cites W2034646599 @default.
- W2076229035 cites W2044747539 @default.
- W2076229035 cites W2046847750 @default.
- W2076229035 cites W2049293477 @default.
- W2076229035 cites W2053181909 @default.
- W2076229035 cites W2055523179 @default.
- W2076229035 cites W2057019886 @default.
- W2076229035 cites W2057495750 @default.
- W2076229035 cites W2059952417 @default.
- W2076229035 cites W2062545296 @default.
- W2076229035 cites W2064625375 @default.
- W2076229035 cites W2075010970 @default.
- W2076229035 cites W2080633177 @default.
- W2076229035 cites W2093688551 @default.
- W2076229035 cites W2104020392 @default.
- W2076229035 cites W2110464595 @default.
- W2076229035 cites W2111737222 @default.
- W2076229035 cites W2128160715 @default.
- W2076229035 cites W2154566941 @default.
- W2076229035 cites W2171668977 @default.
- W2076229035 cites W2288430548 @default.
- W2076229035 cites W2328351515 @default.
- W2076229035 cites W2464500916 @default.
- W2076229035 cites W52737731 @default.
- W2076229035 cites W886044840 @default.
- W2076229035 cites W2028607265 @default.
- W2076229035 doi "https://doi.org/10.1179/174329210x12650506623645" @default.
- W2076229035 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2956440" @default.
- W2076229035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20663292" @default.
- W2076229035 hasPublicationYear "2010" @default.
- W2076229035 type Work @default.
- W2076229035 sameAs 2076229035 @default.
- W2076229035 citedByCount "92" @default.
- W2076229035 countsByYear W20762290352012 @default.
- W2076229035 countsByYear W20762290352013 @default.
- W2076229035 countsByYear W20762290352014 @default.
- W2076229035 countsByYear W20762290352015 @default.
- W2076229035 countsByYear W20762290352016 @default.
- W2076229035 countsByYear W20762290352017 @default.
- W2076229035 countsByYear W20762290352018 @default.
- W2076229035 countsByYear W20762290352019 @default.
- W2076229035 countsByYear W20762290352020 @default.
- W2076229035 countsByYear W20762290352021 @default.
- W2076229035 countsByYear W20762290352022 @default.
- W2076229035 countsByYear W20762290352023 @default.
- W2076229035 crossrefType "journal-article" @default.
- W2076229035 hasAuthorship W2076229035A5001501102 @default.
- W2076229035 hasAuthorship W2076229035A5002609147 @default.
- W2076229035 hasAuthorship W2076229035A5012826249 @default.
- W2076229035 hasAuthorship W2076229035A5021420538 @default.
- W2076229035 hasAuthorship W2076229035A5026442699 @default.
- W2076229035 hasAuthorship W2076229035A5029520152 @default.
- W2076229035 hasAuthorship W2076229035A5041697861 @default.
- W2076229035 hasAuthorship W2076229035A5061884568 @default.
- W2076229035 hasAuthorship W2076229035A5064238762 @default.