Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076229675> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2076229675 endingPage "54" @default.
- W2076229675 startingPage "48" @default.
- W2076229675 abstract "1,3-Butadiene is a carcinogen in rats and mice, with mice being substantially more sensitive than rats. Our recent research is directed toward obtaining a better understanding of the cancer risk of butadiene in humans by evaluating species-dependent differences in the formation of the toxic metabolites epoxybutene and diepoxybutane. The recent data include in vitro studies on butadiene metabolism using tissues from humans, rats, and mice as well as experimental data and physiological model predictions for butadiene in blood and butadiene epoxides in blood, lung, and liver after exposure of rats and mice to inhaled butadiene. The findings suggest that humans would be more like rats and less like mice regarding the formation of butadiene epoxides. These research findings permit a reassessment of some default options that are used in carcinogen risk assessments. The research approach employed can be a useful strategy for developing mechanistic and toxicokinetic data to supplant default assumptions used in carcinogen risk assessments." @default.
- W2076229675 created "2016-06-24" @default.
- W2076229675 creator A5011735913 @default.
- W2076229675 creator A5035254847 @default.
- W2076229675 creator A5051939394 @default.
- W2076229675 creator A5061310769 @default.
- W2076229675 creator A5072806278 @default.
- W2076229675 date "1996-10-01" @default.
- W2076229675 modified "2023-10-14" @default.
- W2076229675 title "Metabolism of butadiene by mice, rats, and humans: a comparison of physiologically based toxicokinetic model predictions and experimental data" @default.
- W2076229675 cites W1978850962 @default.
- W2076229675 cites W1980936504 @default.
- W2076229675 cites W1982765102 @default.
- W2076229675 cites W1991826393 @default.
- W2076229675 cites W1992025559 @default.
- W2076229675 cites W1992874958 @default.
- W2076229675 cites W1994752319 @default.
- W2076229675 cites W2008343066 @default.
- W2076229675 cites W2012166167 @default.
- W2076229675 cites W2013465473 @default.
- W2076229675 cites W2018075333 @default.
- W2076229675 cites W2048326238 @default.
- W2076229675 cites W2048740254 @default.
- W2076229675 cites W2057198691 @default.
- W2076229675 cites W2080658370 @default.
- W2076229675 cites W2081877948 @default.
- W2076229675 cites W2161684776 @default.
- W2076229675 cites W2162609597 @default.
- W2076229675 doi "https://doi.org/10.1016/0300-483x(96)03426-9" @default.
- W2076229675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8901882" @default.
- W2076229675 hasPublicationYear "1996" @default.
- W2076229675 type Work @default.
- W2076229675 sameAs 2076229675 @default.
- W2076229675 citedByCount "17" @default.
- W2076229675 countsByYear W20762296752014 @default.
- W2076229675 countsByYear W20762296752015 @default.
- W2076229675 countsByYear W20762296752018 @default.
- W2076229675 countsByYear W20762296752019 @default.
- W2076229675 countsByYear W20762296752021 @default.
- W2076229675 crossrefType "journal-article" @default.
- W2076229675 hasAuthorship W2076229675A5011735913 @default.
- W2076229675 hasAuthorship W2076229675A5035254847 @default.
- W2076229675 hasAuthorship W2076229675A5051939394 @default.
- W2076229675 hasAuthorship W2076229675A5061310769 @default.
- W2076229675 hasAuthorship W2076229675A5072806278 @default.
- W2076229675 hasConcept C114246631 @default.
- W2076229675 hasConcept C161790260 @default.
- W2076229675 hasConcept C185592680 @default.
- W2076229675 hasConcept C195289149 @default.
- W2076229675 hasConcept C2780887139 @default.
- W2076229675 hasConcept C33070731 @default.
- W2076229675 hasConcept C55493867 @default.
- W2076229675 hasConcept C62231903 @default.
- W2076229675 hasConcept C86803240 @default.
- W2076229675 hasConcept C98274493 @default.
- W2076229675 hasConceptScore W2076229675C114246631 @default.
- W2076229675 hasConceptScore W2076229675C161790260 @default.
- W2076229675 hasConceptScore W2076229675C185592680 @default.
- W2076229675 hasConceptScore W2076229675C195289149 @default.
- W2076229675 hasConceptScore W2076229675C2780887139 @default.
- W2076229675 hasConceptScore W2076229675C33070731 @default.
- W2076229675 hasConceptScore W2076229675C55493867 @default.
- W2076229675 hasConceptScore W2076229675C62231903 @default.
- W2076229675 hasConceptScore W2076229675C86803240 @default.
- W2076229675 hasConceptScore W2076229675C98274493 @default.
- W2076229675 hasIssue "1-3" @default.
- W2076229675 hasLocation W20762296751 @default.
- W2076229675 hasLocation W20762296752 @default.
- W2076229675 hasOpenAccess W2076229675 @default.
- W2076229675 hasPrimaryLocation W20762296751 @default.
- W2076229675 hasRelatedWork W1249098568 @default.
- W2076229675 hasRelatedWork W1537517851 @default.
- W2076229675 hasRelatedWork W2020845560 @default.
- W2076229675 hasRelatedWork W2061790856 @default.
- W2076229675 hasRelatedWork W2063460934 @default.
- W2076229675 hasRelatedWork W2331563585 @default.
- W2076229675 hasRelatedWork W2358529940 @default.
- W2076229675 hasRelatedWork W2375115581 @default.
- W2076229675 hasRelatedWork W2726062789 @default.
- W2076229675 hasRelatedWork W3021733891 @default.
- W2076229675 hasVolume "113" @default.
- W2076229675 isParatext "false" @default.
- W2076229675 isRetracted "false" @default.
- W2076229675 magId "2076229675" @default.
- W2076229675 workType "article" @default.