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- W2076230995 abstract "This report describes a hierarchical screening technique for identification of pathways that control the morphogenesis of the renal collecting duct system. The multi-step screen involves a first round using a 2-dimensional, cell-line-based scrape-healing assay, then a second round using a 3-dimensional tubulogenesis assay; both of these rounds use new cell lines described in this report. The final stage is ex vivo organ culture. We demonstrate the utility of the screen by using it to identify the FAK-Src-pathway signalling as being important for collecting duct development, specifically for the cell proliferation on which this development depends." @default.
- W2076230995 created "2016-06-24" @default.
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- W2076230995 date "2013-02-26" @default.
- W2076230995 modified "2023-09-24" @default.
- W2076230995 title "FAK–Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique" @default.
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- W2076230995 doi "https://doi.org/10.1242/bio.20133780" @default.
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