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• W2076232267 abstract "Complement C3, when its cDNA was transfected into COS-1 cells, was synthesized as a precursor, pro-C3, which was intracellularly processed into the alpha and beta subunits, although not completely. A cDNA for rat alpha 1-protease inhibitor (alpha 1-PI) was mutated in vitro to encode its variant with the modified active site (Met352----Arg). In cells co-transfected with the mutant alpha 1-PI cDNA and the C3 cDNA, pro-C3 expressed was secreted without being processed into the subunits. Co-transfection of the mutant alpha 1-PI cDNA and the albumin cDNA also resulted in the inhibition of intracellular conversion of proalbumin into serum-type albumin. No inhibition of the processing of each preform was observed in cells co-transfected with the normal alpha 1-PI cDNA. Taken together, the results indicate that the alpha 1-PI variant (Met352----Arg) expressed inhibits specifically an intracellular enzyme which is involved in the proteolytic processing of both pro-C3 and proalbumin." @default.
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• W2076232267 date "1990-08-01" @default.
• W2076232267 modified "2023-10-16" @default.
• W2076232267 title "Intracellular processing of complement pro-C3 and proalbumin is inhibited by rat α1-protease inhibitor variant (Met352→Arg) in transfected cells" @default.
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• W2076232267 doi "https://doi.org/10.1016/0006-291x(90)91382-3" @default.
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