FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076236103> ?p ?o ?g. }

• W2076236103 endingPage "171" @default.
• W2076236103 startingPage "165" @default.
• W2076236103 abstract "Nanomagnetic materials offer exciting avenues for probing cell mechanics and activating mechanosensitive ion channels, as well as for advancing cancer therapies. Most experimental works so far have used superparamagnetic materials. This report describes a first approach based on interfacing cells with lithographically defined microdiscs that possess a spin-vortex ground state. When an alternating magnetic field is applied the microdisc vortices shift, creating an oscillation, which transmits a mechanical force to the cell. Because reduced sensitivity of cancer cells toward apoptosis leads to inappropriate cell survival and malignant progression, selective induction of apoptosis is of great importance for the anticancer therapeutic strategies. We show that the spin-vortex-mediated stimulus creates two dramatic effects: compromised integrity of the cellular membrane, and initiation of programmed cell death. A low-frequency field of a few tens of hertz applied for only ten minutes was sufficient to achieve ∼90% cancer-cell destruction in vitro. Biocompatible, lithographically defined, ferromagnetic microdiscs that have a spin-vortex ground state oscillate when activated by an alternating magnetic field. This oscillation compromises the integrity of the cell membrane and initiates programmed cell death in ∼90% of cancer cells in vitro, even with a low-frequency field applied for only ten minutes." @default.
• W2076236103 created "2016-06-24" @default.
• W2076236103 creator A5006920547 @default.
• W2076236103 creator A5007394538 @default.
• W2076236103 creator A5014102411 @default.
• W2076236103 creator A5028737493 @default.
• W2076236103 creator A5033548896 @default.
• W2076236103 creator A5046990451 @default.
• W2076236103 creator A5053972433 @default.
• W2076236103 date "2009-11-29" @default.
• W2076236103 modified "2023-10-09" @default.
• W2076236103 title "Biofunctionalized magnetic-vortex microdiscs for targeted cancer-cell destruction" @default.
• W2076236103 cites W1979474679 @default.
• W2076236103 cites W1980979878 @default.
• W2076236103 cites W2000186632 @default.
• W2076236103 cites W2004205130 @default.
• W2076236103 cites W2009687730 @default.
• W2076236103 cites W2010083809 @default.
• W2076236103 cites W2015716478 @default.
• W2076236103 cites W2019021205 @default.
• W2076236103 cites W2019083595 @default.
• W2076236103 cites W2023396283 @default.
• W2076236103 cites W2025173691 @default.
• W2076236103 cites W2030468762 @default.
• W2076236103 cites W2037997530 @default.
• W2076236103 cites W2043784957 @default.
• W2076236103 cites W2048094211 @default.
• W2076236103 cites W2052766715 @default.
• W2076236103 cites W2057185402 @default.
• W2076236103 cites W2057855113 @default.
• W2076236103 cites W2071659125 @default.
• W2076236103 cites W2074120065 @default.
• W2076236103 cites W2077160965 @default.
• W2076236103 cites W2077526930 @default.
• W2076236103 cites W2078537246 @default.
• W2076236103 cites W2079921510 @default.
• W2076236103 cites W2081672461 @default.
• W2076236103 cites W2099525573 @default.
• W2076236103 cites W2114584719 @default.
• W2076236103 cites W2125942201 @default.
• W2076236103 cites W2149184721 @default.
• W2076236103 cites W2151728303 @default.
• W2076236103 cites W2158558808 @default.
• W2076236103 cites W2172176216 @default.
• W2076236103 cites W3007599434 @default.
• W2076236103 cites W4249424055 @default.
• W2076236103 doi "https://doi.org/10.1038/nmat2591" @default.
• W2076236103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2810356" @default.
• W2076236103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19946279" @default.
• W2076236103 hasPublicationYear "2009" @default.
• W2076236103 type Work @default.
• W2076236103 sameAs 2076236103 @default.
• W2076236103 citedByCount "489" @default.
• W2076236103 countsByYear W20762361032012 @default.
• W2076236103 countsByYear W20762361032013 @default.
• W2076236103 countsByYear W20762361032014 @default.
• W2076236103 countsByYear W20762361032015 @default.
• W2076236103 countsByYear W20762361032016 @default.
• W2076236103 countsByYear W20762361032017 @default.
• W2076236103 countsByYear W20762361032018 @default.
• W2076236103 countsByYear W20762361032019 @default.
• W2076236103 countsByYear W20762361032020 @default.
• W2076236103 countsByYear W20762361032021 @default.
• W2076236103 countsByYear W20762361032022 @default.
• W2076236103 countsByYear W20762361032023 @default.
• W2076236103 crossrefType "journal-article" @default.
• W2076236103 hasAuthorship W2076236103A5006920547 @default.
• W2076236103 hasAuthorship W2076236103A5007394538 @default.
• W2076236103 hasAuthorship W2076236103A5014102411 @default.
• W2076236103 hasAuthorship W2076236103A5028737493 @default.
• W2076236103 hasAuthorship W2076236103A5033548896 @default.
• W2076236103 hasAuthorship W2076236103A5046990451 @default.
• W2076236103 hasAuthorship W2076236103A5053972433 @default.
• W2076236103 hasBestOaLocation W20762361032 @default.
• W2076236103 hasConcept C121608353 @default.
• W2076236103 hasConcept C126322002 @default.
• W2076236103 hasConcept C1491633281 @default.
• W2076236103 hasConcept C170493617 @default.
• W2076236103 hasConcept C171250308 @default.
• W2076236103 hasConcept C185592680 @default.
• W2076236103 hasConcept C190283241 @default.
• W2076236103 hasConcept C192562407 @default.
• W2076236103 hasConcept C4001165 @default.
• W2076236103 hasConcept C50254741 @default.
• W2076236103 hasConcept C55493867 @default.
• W2076236103 hasConcept C71924100 @default.
• W2076236103 hasConcept C96232424 @default.
• W2076236103 hasConceptScore W2076236103C121608353 @default.
• W2076236103 hasConceptScore W2076236103C126322002 @default.
• W2076236103 hasConceptScore W2076236103C1491633281 @default.
• W2076236103 hasConceptScore W2076236103C170493617 @default.
• W2076236103 hasConceptScore W2076236103C171250308 @default.
• W2076236103 hasConceptScore W2076236103C185592680 @default.
• W2076236103 hasConceptScore W2076236103C190283241 @default.
• W2076236103 hasConceptScore W2076236103C192562407 @default.
• W2076236103 hasConceptScore W2076236103C4001165 @default.
• W2076236103 hasConceptScore W2076236103C50254741 @default.
• W2076236103 hasConceptScore W2076236103C55493867 @default.

• next