Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076239278> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2076239278 endingPage "627" @default.
- W2076239278 startingPage "620" @default.
- W2076239278 abstract "When the HhaI (cytosine-5) methyltransferase (M.HhaI) binds DNA it causes the target cytosine to be flipped 180 degrees out of the helix. The space becomes occupied by two amino acids, Ser-87 and Gln-237, which enter the helix from opposite sides and form a hydrogen bond to each other. Gln-237 may be involved in specific sequence recognition since it forms three hydrogen bonds to the orphan guanosine, which is the partner of the target cytosine. We have prepared all 19 mutants of Gln-237 and tested their biochemical properties. We find that mutations of this residue greatly affect the stability of the M.HhaI-DNA complex without affecting the enzyme's specificity for the target sequence. Surprisingly, all mutants retain detectable levels of enzymatic activity." @default.
- W2076239278 created "2016-06-24" @default.
- W2076239278 creator A5007228345 @default.
- W2076239278 creator A5059125322 @default.
- W2076239278 creator A5091034547 @default.
- W2076239278 date "1995-01-01" @default.
- W2076239278 modified "2023-09-23" @default.
- W2076239278 title "Functional analysis of Gln-237 mutants of<i>Hha</i>l methyltransferase" @default.
- W2076239278 cites W1546173806 @default.
- W2076239278 cites W1585338920 @default.
- W2076239278 cites W1588090370 @default.
- W2076239278 cites W1668326091 @default.
- W2076239278 cites W1994162276 @default.
- W2076239278 cites W2020760968 @default.
- W2076239278 cites W2034056708 @default.
- W2076239278 cites W2034602099 @default.
- W2076239278 cites W2036974136 @default.
- W2076239278 cites W2055565613 @default.
- W2076239278 cites W2055690563 @default.
- W2076239278 cites W2073287325 @default.
- W2076239278 cites W2076911571 @default.
- W2076239278 cites W2080779417 @default.
- W2076239278 cites W2088024226 @default.
- W2076239278 cites W2150787553 @default.
- W2076239278 cites W2158268918 @default.
- W2076239278 doi "https://doi.org/10.1093/nar/23.4.620" @default.
- W2076239278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/306729" @default.
- W2076239278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7899082" @default.
- W2076239278 hasPublicationYear "1995" @default.
- W2076239278 type Work @default.
- W2076239278 sameAs 2076239278 @default.
- W2076239278 citedByCount "38" @default.
- W2076239278 countsByYear W20762392782012 @default.
- W2076239278 countsByYear W20762392782015 @default.
- W2076239278 countsByYear W20762392782018 @default.
- W2076239278 crossrefType "journal-article" @default.
- W2076239278 hasAuthorship W2076239278A5007228345 @default.
- W2076239278 hasAuthorship W2076239278A5059125322 @default.
- W2076239278 hasAuthorship W2076239278A5091034547 @default.
- W2076239278 hasBestOaLocation W20762392782 @default.
- W2076239278 hasConcept C104317684 @default.
- W2076239278 hasConcept C143065580 @default.
- W2076239278 hasConcept C153911025 @default.
- W2076239278 hasConcept C2776023528 @default.
- W2076239278 hasConcept C2777995097 @default.
- W2076239278 hasConcept C2778301229 @default.
- W2076239278 hasConcept C33288867 @default.
- W2076239278 hasConcept C501734568 @default.
- W2076239278 hasConcept C512185932 @default.
- W2076239278 hasConcept C54355233 @default.
- W2076239278 hasConcept C552990157 @default.
- W2076239278 hasConcept C55493867 @default.
- W2076239278 hasConcept C86803240 @default.
- W2076239278 hasConcept C91965660 @default.
- W2076239278 hasConceptScore W2076239278C104317684 @default.
- W2076239278 hasConceptScore W2076239278C143065580 @default.
- W2076239278 hasConceptScore W2076239278C153911025 @default.
- W2076239278 hasConceptScore W2076239278C2776023528 @default.
- W2076239278 hasConceptScore W2076239278C2777995097 @default.
- W2076239278 hasConceptScore W2076239278C2778301229 @default.
- W2076239278 hasConceptScore W2076239278C33288867 @default.
- W2076239278 hasConceptScore W2076239278C501734568 @default.
- W2076239278 hasConceptScore W2076239278C512185932 @default.
- W2076239278 hasConceptScore W2076239278C54355233 @default.
- W2076239278 hasConceptScore W2076239278C552990157 @default.
- W2076239278 hasConceptScore W2076239278C55493867 @default.
- W2076239278 hasConceptScore W2076239278C86803240 @default.
- W2076239278 hasConceptScore W2076239278C91965660 @default.
- W2076239278 hasIssue "4" @default.
- W2076239278 hasLocation W20762392781 @default.
- W2076239278 hasLocation W20762392782 @default.
- W2076239278 hasLocation W20762392783 @default.
- W2076239278 hasLocation W20762392784 @default.
- W2076239278 hasOpenAccess W2076239278 @default.
- W2076239278 hasPrimaryLocation W20762392781 @default.
- W2076239278 hasRelatedWork W119765381 @default.
- W2076239278 hasRelatedWork W1966127978 @default.
- W2076239278 hasRelatedWork W1972854948 @default.
- W2076239278 hasRelatedWork W1974371829 @default.
- W2076239278 hasRelatedWork W1985445036 @default.
- W2076239278 hasRelatedWork W2006910918 @default.
- W2076239278 hasRelatedWork W2033360561 @default.
- W2076239278 hasRelatedWork W2038528212 @default.
- W2076239278 hasRelatedWork W2259662017 @default.
- W2076239278 hasRelatedWork W2316931891 @default.
- W2076239278 hasVolume "23" @default.
- W2076239278 isParatext "false" @default.
- W2076239278 isRetracted "false" @default.
- W2076239278 magId "2076239278" @default.
- W2076239278 workType "article" @default.