FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076244588> ?p ?o ?g. }

• W2076244588 endingPage "240" @default.
• W2076244588 startingPage "233" @default.
• W2076244588 abstract "Dextromethorphan (DM) is a dextrorotatory morphinan and an over-the-counter non-opioid cough suppressant. We have previously shown that DM protects against LPS-induced dopaminergic neurodegeneration through inhibition of microglia activation. Here, we investigated protective effects of DM against endotoxin shock induced by lipopolysaccharide/d-galactosamine (LPS/GalN) in mice and the mechanism underlying its protective effect. Mice were given multiple injections of DM (12.5 mg/kg, s.c.) 30 min before and 2, 4 h after an injection of LPS/GalN (20 μg/700 mg/kg). DM administration decreased LPS/GalN-induced mortality and hepatotoxicity, as evidenced by increased survival rate, decreased serum alanine aminotransferase activity and improved pathology. Furthermore, DM was also effective when it was given 30 min after LPS/GalN injection. The protection was likely associated with reduced serum and liver tumor necrosis factor alpha (TNF-α) levels. DM also attenuated production of superoxide and intracellular reactive oxygen species in Kupffer cells and neutrophils. Real-time RT-PCR analysis revealed that DM administration suppressed the expression of a variety of inflammation-related genes such as macrophage inflammatory protein-2, CXC chemokine, thrombospondin-1, intercellular adhesion molecular-1 and interleukin-6. DM also decreased the expression of genes related to cell-death pathways, such as the DNA damage protein genes GADD45 and GADD153. In summary, DM is effective in protecting mice against LPS/GalN-induced hepatotoxicity, and the mechanism is likely through a faster TNF-α clearance, and decrease of superoxide production and inflammation and cell-death related components. This study not only extends neuroprotective effect of DM, but also suggests that DM may be a novel compound for the therapeutic intervention for sepsis." @default.
• W2076244588 created "2016-06-24" @default.
• W2076244588 creator A5000947537 @default.
• W2076244588 creator A5007798397 @default.
• W2076244588 creator A5034408789 @default.
• W2076244588 creator A5036055830 @default.
• W2076244588 creator A5042830817 @default.
• W2076244588 creator A5048826252 @default.
• W2076244588 creator A5051864089 @default.
• W2076244588 creator A5061275884 @default.
• W2076244588 creator A5066935802 @default.
• W2076244588 creator A5071852918 @default.
• W2076244588 creator A5086252890 @default.
• W2076244588 date "2005-01-01" @default.
• W2076244588 modified "2023-10-18" @default.
• W2076244588 title "Protective effect of dextromethorphan against endotoxic shock in mice" @default.
• W2076244588 cites W1541649582 @default.
• W2076244588 cites W1968666033 @default.
• W2076244588 cites W196899815 @default.
• W2076244588 cites W1992390260 @default.
• W2076244588 cites W1999212699 @default.
• W2076244588 cites W2028178959 @default.
• W2076244588 cites W2032643739 @default.
• W2076244588 cites W2039190334 @default.
• W2076244588 cites W2049714321 @default.
• W2076244588 cites W2052374880 @default.
• W2076244588 cites W2053338918 @default.
• W2076244588 cites W2053483725 @default.
• W2076244588 cites W2054789114 @default.
• W2076244588 cites W2063991756 @default.
• W2076244588 cites W2073976519 @default.
• W2076244588 cites W2081832811 @default.
• W2076244588 cites W2085733748 @default.
• W2076244588 cites W2092289140 @default.
• W2076244588 cites W2093521608 @default.
• W2076244588 cites W2098650898 @default.
• W2076244588 cites W2111202522 @default.
• W2076244588 cites W2117825601 @default.
• W2076244588 cites W2120180999 @default.
• W2076244588 cites W2123672512 @default.
• W2076244588 cites W2127233792 @default.
• W2076244588 cites W2137028339 @default.
• W2076244588 cites W2142754219 @default.
• W2076244588 cites W2144847280 @default.
• W2076244588 cites W2158019652 @default.
• W2076244588 cites W2165251432 @default.
• W2076244588 cites W2323098151 @default.
• W2076244588 cites W384075993 @default.
• W2076244588 doi "https://doi.org/10.1016/j.bcp.2004.10.003" @default.
• W2076244588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15627475" @default.
• W2076244588 hasPublicationYear "2005" @default.
• W2076244588 type Work @default.
• W2076244588 sameAs 2076244588 @default.
• W2076244588 citedByCount "53" @default.
• W2076244588 countsByYear W20762445882012 @default.
• W2076244588 countsByYear W20762445882013 @default.
• W2076244588 countsByYear W20762445882014 @default.
• W2076244588 countsByYear W20762445882015 @default.
• W2076244588 countsByYear W20762445882016 @default.
• W2076244588 countsByYear W20762445882017 @default.
• W2076244588 countsByYear W20762445882019 @default.
• W2076244588 countsByYear W20762445882020 @default.
• W2076244588 countsByYear W20762445882022 @default.
• W2076244588 countsByYear W20762445882023 @default.
• W2076244588 crossrefType "journal-article" @default.
• W2076244588 hasAuthorship W2076244588A5000947537 @default.
• W2076244588 hasAuthorship W2076244588A5007798397 @default.
• W2076244588 hasAuthorship W2076244588A5034408789 @default.
• W2076244588 hasAuthorship W2076244588A5036055830 @default.
• W2076244588 hasAuthorship W2076244588A5042830817 @default.
• W2076244588 hasAuthorship W2076244588A5048826252 @default.
• W2076244588 hasAuthorship W2076244588A5051864089 @default.
• W2076244588 hasAuthorship W2076244588A5061275884 @default.
• W2076244588 hasAuthorship W2076244588A5066935802 @default.
• W2076244588 hasAuthorship W2076244588A5071852918 @default.
• W2076244588 hasAuthorship W2076244588A5086252890 @default.
• W2076244588 hasConcept C13373296 @default.
• W2076244588 hasConcept C134018914 @default.
• W2076244588 hasConcept C17991360 @default.
• W2076244588 hasConcept C185592680 @default.
• W2076244588 hasConcept C203014093 @default.
• W2076244588 hasConcept C2776637226 @default.
• W2076244588 hasConcept C2776914184 @default.
• W2076244588 hasConcept C2778754761 @default.
• W2076244588 hasConcept C2781245242 @default.
• W2076244588 hasConcept C86803240 @default.
• W2076244588 hasConcept C98274493 @default.
• W2076244588 hasConceptScore W2076244588C13373296 @default.
• W2076244588 hasConceptScore W2076244588C134018914 @default.
• W2076244588 hasConceptScore W2076244588C17991360 @default.
• W2076244588 hasConceptScore W2076244588C185592680 @default.
• W2076244588 hasConceptScore W2076244588C203014093 @default.
• W2076244588 hasConceptScore W2076244588C2776637226 @default.
• W2076244588 hasConceptScore W2076244588C2776914184 @default.
• W2076244588 hasConceptScore W2076244588C2778754761 @default.
• W2076244588 hasConceptScore W2076244588C2781245242 @default.
• W2076244588 hasConceptScore W2076244588C86803240 @default.
• W2076244588 hasConceptScore W2076244588C98274493 @default.

• next