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- W2076246961 endingPage "941" @default.
- W2076246961 startingPage "933" @default.
- W2076246961 abstract "The development of antibodies against blood clotting factor VIII is a major complication affecting 20-30% of hemophilia A patients receiving replacement with FVIII concentrates. This study investigated generating peptides acting as broadly neutralizing agents to block factor VIII antibodies. These peptides were selected from dual positional scanning decapeptide libraries on cellulose membranes. From this library comprising 6.8 x 10(12) peptides we selected 468 peptides for further screening rounds. Finally we identified two decapeptides with the ability to block 8 out of 10 inhibitory antibodies from sera of patients with FVIII inhibitors demonstrated by competition assays. Sequence alignment of the peptides showed similarity with several domains in the FVIII molecule demonstrating the mimotope nature of the selected peptides. Our results show the efficiency of the combinatorial library approach and show the potential of combinatorial peptides to compete out polyclonal inhibitor IgG from a broad range of patients' sera. Combinatorial peptides could be novel and highly effective drug candidates for alternative treatment in patients with factor VIII inhibitors." @default.
- W2076246961 created "2016-06-24" @default.
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- W2076246961 date "2005-01-01" @default.
- W2076246961 modified "2023-09-27" @default.
- W2076246961 title "Combinatorial peptides directed to inhibitory antibodies against human blood clotting factor VIII" @default.
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- W2076246961 doi "https://doi.org/10.1160/th05-04-0254" @default.
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