FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076249178> ?p ?o ?g. }

• W2076249178 endingPage "806" @default.
• W2076249178 startingPage "803" @default.
• W2076249178 abstract "A series of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N′-(6,6-fused heterocyclic) ureas have been investigated as hTRPV1 antagonists. Among them, compound 15 showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant) = 0.2 nM, as well as antagonism to other activators, and it was efficacious in a pain model. A docking study of 15 with our hTRPV1 homology model indicates that there is crucial hydrogen bonding between the ring nitrogen and the receptor, contributing to its potency." @default.
• W2076249178 created "2016-06-24" @default.
• W2076249178 creator A5000110760 @default.
• W2076249178 creator A5000439028 @default.
• W2076249178 creator A5001712204 @default.
• W2076249178 creator A5001838194 @default.
• W2076249178 creator A5004618453 @default.
• W2076249178 creator A5005017111 @default.
• W2076249178 creator A5005572021 @default.
• W2076249178 creator A5006581729 @default.
• W2076249178 creator A5010714518 @default.
• W2076249178 creator A5016220974 @default.
• W2076249178 creator A5026887613 @default.
• W2076249178 creator A5038545965 @default.
• W2076249178 creator A5040225665 @default.
• W2076249178 creator A5044741319 @default.
• W2076249178 creator A5062609911 @default.
• W2076249178 creator A5064081580 @default.
• W2076249178 creator A5073460030 @default.
• W2076249178 date "2015-02-01" @default.
• W2076249178 modified "2023-10-07" @default.
• W2076249178 title "6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists" @default.
• W2076249178 cites W1968495593 @default.
• W2076249178 cites W1968901322 @default.
• W2076249178 cites W1972359448 @default.
• W2076249178 cites W1982629087 @default.
• W2076249178 cites W1985396076 @default.
• W2076249178 cites W1986697368 @default.
• W2076249178 cites W2001834513 @default.
• W2076249178 cites W2018814467 @default.
• W2076249178 cites W2020158187 @default.
• W2076249178 cites W2035429056 @default.
• W2076249178 cites W2052654049 @default.
• W2076249178 cites W2053170393 @default.
• W2076249178 cites W2057681671 @default.
• W2076249178 cites W2094758067 @default.
• W2076249178 cites W2146450271 @default.
• W2076249178 cites W2153505330 @default.
• W2076249178 cites W2949183871 @default.
• W2076249178 cites W2950458971 @default.
• W2076249178 cites W4234591059 @default.
• W2076249178 doi "https://doi.org/10.1016/j.bmcl.2014.12.086" @default.
• W2076249178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25597011" @default.
• W2076249178 hasPublicationYear "2015" @default.
• W2076249178 type Work @default.
• W2076249178 sameAs 2076249178 @default.
• W2076249178 citedByCount "5" @default.
• W2076249178 countsByYear W20762491782016 @default.
• W2076249178 countsByYear W20762491782019 @default.
• W2076249178 countsByYear W20762491782020 @default.
• W2076249178 countsByYear W20762491782022 @default.
• W2076249178 countsByYear W20762491782023 @default.
• W2076249178 crossrefType "journal-article" @default.
• W2076249178 hasAuthorship W2076249178A5000110760 @default.
• W2076249178 hasAuthorship W2076249178A5000439028 @default.
• W2076249178 hasAuthorship W2076249178A5001712204 @default.
• W2076249178 hasAuthorship W2076249178A5001838194 @default.
• W2076249178 hasAuthorship W2076249178A5004618453 @default.
• W2076249178 hasAuthorship W2076249178A5005017111 @default.
• W2076249178 hasAuthorship W2076249178A5005572021 @default.
• W2076249178 hasAuthorship W2076249178A5006581729 @default.
• W2076249178 hasAuthorship W2076249178A5010714518 @default.
• W2076249178 hasAuthorship W2076249178A5016220974 @default.
• W2076249178 hasAuthorship W2076249178A5026887613 @default.
• W2076249178 hasAuthorship W2076249178A5038545965 @default.
• W2076249178 hasAuthorship W2076249178A5040225665 @default.
• W2076249178 hasAuthorship W2076249178A5044741319 @default.
• W2076249178 hasAuthorship W2076249178A5062609911 @default.
• W2076249178 hasAuthorship W2076249178A5064081580 @default.
• W2076249178 hasAuthorship W2076249178A5073460030 @default.
• W2076249178 hasConcept C112887158 @default.
• W2076249178 hasConcept C155164980 @default.
• W2076249178 hasConcept C159110408 @default.
• W2076249178 hasConcept C160145004 @default.
• W2076249178 hasConcept C169627665 @default.
• W2076249178 hasConcept C170493617 @default.
• W2076249178 hasConcept C178790620 @default.
• W2076249178 hasConcept C181199279 @default.
• W2076249178 hasConcept C185592680 @default.
• W2076249178 hasConcept C202751555 @default.
• W2076249178 hasConcept C2776442012 @default.
• W2076249178 hasConcept C2777383412 @default.
• W2076249178 hasConcept C2780051329 @default.
• W2076249178 hasConcept C2780263894 @default.
• W2076249178 hasConcept C2780378348 @default.
• W2076249178 hasConcept C32909587 @default.
• W2076249178 hasConcept C41685203 @default.
• W2076249178 hasConcept C55493867 @default.
• W2076249178 hasConcept C57992300 @default.
• W2076249178 hasConcept C71240020 @default.
• W2076249178 hasConcept C71924100 @default.
• W2076249178 hasConcept C98274493 @default.
• W2076249178 hasConceptScore W2076249178C112887158 @default.
• W2076249178 hasConceptScore W2076249178C155164980 @default.
• W2076249178 hasConceptScore W2076249178C159110408 @default.
• W2076249178 hasConceptScore W2076249178C160145004 @default.
• W2076249178 hasConceptScore W2076249178C169627665 @default.
• W2076249178 hasConceptScore W2076249178C170493617 @default.

• next