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- W2076249680 abstract "DNA double-strand breaks can be repaired by homologous recombination, during which the DNA ends are long-range resected by helicase–nuclease systems to generate 3′ single strand tails. In archaea, this requires the Mre11–Rad50 complex and the ATP-dependent helicase–nuclease complex HerA–NurA. We report the cryo-EM structure of Sulfolobus solfataricus HerA–NurA at 7.4 Å resolution and present the pseudo-atomic model of the complex. HerA forms an ASCE hexamer that tightly interacts with a NurA dimer, with each NurA protomer binding three adjacent HerA HAS domains. Entry to NurA's nuclease active sites requires dsDNA to pass through a 23 Å wide channel in the HerA hexamer. The structure suggests that HerA is a dsDNA translocase that feeds DNA into the NurA nuclease sites." @default.
- W2076249680 created "2016-06-24" @default.
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- W2076249680 date "2014-11-11" @default.
- W2076249680 modified "2023-10-18" @default.
- W2076249680 title "Molecular architecture of the HerA-NurA DNA double-strand break resection complex" @default.
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- W2076249680 doi "https://doi.org/10.1016/j.febslet.2014.10.035" @default.
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