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- W2076253189 abstract "INFECTIOUS complications of BCG vaccination and immunotherapy have been rare, even in immunosuppressed patients who have responded readily to two to four months of isoniazid therapy. 1,2 We report a case in which accidental BCG inoculation led to a localized hand infection that failed to respond to three months of isoniazid therapy. Report of a Case On Sept 10, 1975, a physician engaged in laboratory research accidentally inoculated the dorsum of her right index finger over the distal interphalangeal joint with BCG diluted in saline. It is estimated that she received a maximum of 12 × 10 7 colonyforming units. Over the next two days the finger became painful and swollen, and two weeks later an ulcerative lesion developed at the injection site. A smear of the lesion showed acid-fast bacilli, and cultures grew an organism subsequently identified as BCG. After three months of isoniazid treatment (300 mg/day), there was" @default.
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- W2076253189 date "1977-07-04" @default.
- W2076253189 modified "2023-09-24" @default.
- W2076253189 title "Failure of Isoniazid to Cure Localized BCG Infection" @default.
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- W2076253189 doi "https://doi.org/10.1001/jama.1977.03280010055023" @default.
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