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• W2076254013 abstract "The optimal duration of concomitant antibiotic therapy after surgical intervention for implant-free chronic osteomyelitis is unknown. No randomized data exist. Available recommendations are based on expert’s opinion. We evaluated the duration of post-surgical antibiotic treatment related to remission of chronic osteomyelitis. This was a retrospective single-centre study at Geneva University Hospitals with a minimal follow-up of two years after treatment. We used multivariate logistic regression analysis with exclusion of pediatric cases and of implant-related chronic osteomyelitis. A total of 49 episodes of implant-free chronic osteomyelitis in 49 adult patients were studied. The median number of surgical interventions was two (range, 1–10). The median duration of post-debridement antibiotic treatment was eight weeks (range, 4–14 weeks). Thirty-nine patients (80%) were in remission after a minimal follow-up of two years. In multivariate logistic regression analysis, one week of intravenous therapy had the same remission as two to three weeks (0.2, 0.1–1.9) or ≥ 3 weeks (0.3, 0.1–2.4). More than six weeks of total antibiotic treatment equalled ≤ six weeks (0.8, 0.1–5.2). In chronic osteomyelitis in adults, a post-debridement antibiotic therapy beyond six weeks, or an IV treatment longer than one week, did not show enhanced remission incidences. Prospective randomized trials are required to confirm this observation." @default.
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• W2076254013 date "2011-02-12" @default.
• W2076254013 modified "2023-10-17" @default.
• W2076254013 title "Duration of post-surgical antibiotic therapy for adult chronic osteomyelitis: a single-centre experience" @default.
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• W2076254013 doi "https://doi.org/10.1007/s00264-011-1221-y" @default.
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