FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076254268> ?p ?o ?g. }

• W2076254268 abstract "Breathing and blood pressure are under constant homeostatic regulation to maintain optimal oxygen delivery to the tissues. Chemosensory reflexes initiated by the carotid body and catecholamine secretion from the adrenal medulla are the principal mechanisms for maintaining respiratory and cardiovascular homeostasis; however, the underlying molecular mechanisms are not known. Here, we report that balanced activity of hypoxia-inducible factor-1 (HIF-1) and HIF-2 is critical for oxygen sensing by the carotid body and adrenal medulla, and for their control of cardio-respiratory function. In Hif2α +/− mice, partial HIF-2α deficiency increased levels of HIF-1α and NADPH oxidase 2, leading to an oxidized intracellular redox state, exaggerated hypoxic sensitivity, and cardio-respiratory abnormalities, which were reversed by treatment with a HIF-1α inhibitor or a superoxide anion scavenger. Conversely, in Hif1α +/− mice, partial HIF-1α deficiency increased levels of HIF-2α and superoxide dismutase 2, leading to a reduced intracellular redox state, blunted oxygen sensing, and impaired carotid body and ventilatory responses to chronic hypoxia, which were corrected by treatment with a HIF-2α inhibitor. None of the abnormalities observed in Hif1α +/− mice or Hif2α +/− mice were observed in Hif1α +/− ; Hif2α +/− mice. These observations demonstrate that redox balance, which is determined by mutual antagonism between HIF-α isoforms, establishes the set point for hypoxic sensing by the carotid body and adrenal medulla, and is required for maintenance of cardio-respiratory homeostasis." @default.
• W2076254268 created "2016-06-24" @default.
• W2076254268 creator A5004128762 @default.
• W2076254268 creator A5031114280 @default.
• W2076254268 creator A5051276665 @default.
• W2076254268 creator A5054833047 @default.
• W2076254268 creator A5056093369 @default.
• W2076254268 creator A5060388980 @default.
• W2076254268 creator A5064414704 @default.
• W2076254268 creator A5066157393 @default.
• W2076254268 creator A5077460832 @default.
• W2076254268 creator A5085500722 @default.
• W2076254268 date "2013-04-22" @default.
• W2076254268 modified "2023-10-16" @default.
• W2076254268 title "Mutual antagonism between hypoxia-inducible factors 1α and 2α regulates oxygen sensing and cardio-respiratory homeostasis" @default.
• W2076254268 cites W1576829667 @default.
• W2076254268 cites W1744173909 @default.
• W2076254268 cites W1966475752 @default.
• W2076254268 cites W1967390196 @default.
• W2076254268 cites W1968576027 @default.
• W2076254268 cites W1982030800 @default.
• W2076254268 cites W1988377666 @default.
• W2076254268 cites W1998664010 @default.
• W2076254268 cites W2008430621 @default.
• W2076254268 cites W2021656373 @default.
• W2076254268 cites W2029767812 @default.
• W2076254268 cites W2038010178 @default.
• W2076254268 cites W2041388890 @default.
• W2076254268 cites W2046080313 @default.
• W2076254268 cites W2046788982 @default.
• W2076254268 cites W2063821082 @default.
• W2076254268 cites W2070178026 @default.
• W2076254268 cites W2073393692 @default.
• W2076254268 cites W2087377825 @default.
• W2076254268 cites W2088239014 @default.
• W2076254268 cites W2098972920 @default.
• W2076254268 cites W2102476325 @default.
• W2076254268 cites W2102941087 @default.
• W2076254268 cites W2120657231 @default.
• W2076254268 cites W2120788437 @default.
• W2076254268 cites W2122533794 @default.
• W2076254268 cites W2135664375 @default.
• W2076254268 cites W2153376781 @default.
• W2076254268 cites W2157849239 @default.
• W2076254268 cites W2162484465 @default.
• W2076254268 cites W2336038108 @default.
• W2076254268 cites W2420420722 @default.
• W2076254268 cites W2580449060 @default.
• W2076254268 cites W57094281 @default.
• W2076254268 doi "https://doi.org/10.1073/pnas.1305961110" @default.
• W2076254268 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3651442" @default.
• W2076254268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23610397" @default.
• W2076254268 hasPublicationYear "2013" @default.
• W2076254268 type Work @default.
• W2076254268 sameAs 2076254268 @default.
• W2076254268 citedByCount "70" @default.
• W2076254268 countsByYear W20762542682013 @default.
• W2076254268 countsByYear W20762542682014 @default.
• W2076254268 countsByYear W20762542682015 @default.
• W2076254268 countsByYear W20762542682016 @default.
• W2076254268 countsByYear W20762542682017 @default.
• W2076254268 countsByYear W20762542682018 @default.
• W2076254268 countsByYear W20762542682020 @default.
• W2076254268 countsByYear W20762542682021 @default.
• W2076254268 countsByYear W20762542682022 @default.
• W2076254268 countsByYear W20762542682023 @default.
• W2076254268 crossrefType "journal-article" @default.
• W2076254268 hasAuthorship W2076254268A5004128762 @default.
• W2076254268 hasAuthorship W2076254268A5031114280 @default.
• W2076254268 hasAuthorship W2076254268A5051276665 @default.
• W2076254268 hasAuthorship W2076254268A5054833047 @default.
• W2076254268 hasAuthorship W2076254268A5056093369 @default.
• W2076254268 hasAuthorship W2076254268A5060388980 @default.
• W2076254268 hasAuthorship W2076254268A5064414704 @default.
• W2076254268 hasAuthorship W2076254268A5066157393 @default.
• W2076254268 hasAuthorship W2076254268A5077460832 @default.
• W2076254268 hasAuthorship W2076254268A5085500722 @default.
• W2076254268 hasBestOaLocation W20762542681 @default.
• W2076254268 hasConcept C104317684 @default.
• W2076254268 hasConcept C126322002 @default.
• W2076254268 hasConcept C134018914 @default.
• W2076254268 hasConcept C160450060 @default.
• W2076254268 hasConcept C178790620 @default.
• W2076254268 hasConcept C185592680 @default.
• W2076254268 hasConcept C24998067 @default.
• W2076254268 hasConcept C2778113364 @default.
• W2076254268 hasConcept C534529494 @default.
• W2076254268 hasConcept C540031477 @default.
• W2076254268 hasConcept C55493867 @default.
• W2076254268 hasConcept C63645605 @default.
• W2076254268 hasConcept C71924100 @default.
• W2076254268 hasConcept C7836513 @default.
• W2076254268 hasConcept C86803240 @default.
• W2076254268 hasConceptScore W2076254268C104317684 @default.
• W2076254268 hasConceptScore W2076254268C126322002 @default.
• W2076254268 hasConceptScore W2076254268C134018914 @default.
• W2076254268 hasConceptScore W2076254268C160450060 @default.
• W2076254268 hasConceptScore W2076254268C178790620 @default.
• W2076254268 hasConceptScore W2076254268C185592680 @default.
• W2076254268 hasConceptScore W2076254268C24998067 @default.

• next