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• W2076254833 abstract "For immune diagnostic purposes it would be critical to be able to distinguish between ongoing immune processes, such as active infections, and long-term immune memory, for example imprinted by infections that have been cleared a long time ago or by vaccinations. We tested the hypothesis that the secretion of granzyme B, as detected in ex vivo ELISPOT assays, permits this distinction. We studied EBV-, flu- and CMV-specific CD8(+) cells in healthy individuals, Vaccinia virus-reactive CD8(+) cells in the course of vaccination, and HIV-specific CD8(+) cells in HIV-infected individuals. Antigen-specific ex vivo GzB production was detected only transiently after Vaccinia immunization, and in HIV-infected individuals. Our data suggest that ex vivo ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8(+) cell responses-a notion that is pertinent to the immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development." @default.
• W2076254833 created "2016-06-24" @default.
• W2076254833 creator A5001086144 @default.
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• W2076254833 date "2007-05-01" @default.
• W2076254833 modified "2023-10-16" @default.
• W2076254833 title "Granzyme B production distinguishes recently activated CD8+ memory cells from resting memory cells" @default.
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• W2076254833 doi "https://doi.org/10.1016/j.cellimm.2007.07.004" @default.
• W2076254833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2134935" @default.
• W2076254833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17825804" @default.
• W2076254833 hasPublicationYear "2007" @default.
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