FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076255384> ?p ?o ?g. }

• W2076255384 endingPage "281" @default.
• W2076255384 startingPage "267" @default.
• W2076255384 abstract "The extracellular signal-regulated kinases 1 and 2 (ERKs 1/2) are known to participate in regulating transcription in response to moderate depolarization, such as synaptic stimulation, but how the same active enzyme can differentially regulate distinct transcriptional programs induced with abnormal depolarization (high potassium) is unknown. We hypothesized that ERK1 or 2 accomplishes this differential nuclear response through close association with other proteins in stable complexes. In support of this hypothesis, we have found that immunoreactivity for an apparent high molecular weight complex containing phospho-ERK1 increased in response to synaptic stimulation, but decreased in response to high potassium; p-ERK immunoreactivity at 44/42 kDa increased in both cases. Evidence supporting the conclusion that the band of interest contained ERK1 in a complex, as opposed to it being an unrelated protein crossreacting with antibodies against p-ERK, is that ERK1 (p44 MAPK) and 14-3-3 protein were electroeluted from the 160-kDa band cut from a gel. We also found the nuclear complexes to be exceptionally durable, suggesting a role for the crosslinking enzyme, transglutaminase, in its stabilization. In addition, we found other components of the ERK pathway, including MEK, ERK2, p90RSK, and Elk-1, migrating at higher-than-expected weights in brain nuclei. These results describe a novel stable complex of ERK1 in neuronal nuclei that responds differentially to synaptic and depolarizing stimulation, and thus may be capable of mediating gene transcription in a way distinct from the monomeric protein." @default.
• W2076255384 created "2016-06-24" @default.
• W2076255384 creator A5005573844 @default.
• W2076255384 creator A5030710357 @default.
• W2076255384 date "2006-12-01" @default.
• W2076255384 modified "2023-09-26" @default.
• W2076255384 title "Differential activation of extracellular signal-regulated kinase 1 and a related complex in neuronal nuclei" @default.
• W2076255384 cites W1481299355 @default.
• W2076255384 cites W1554441317 @default.
• W2076255384 cites W1581556098 @default.
• W2076255384 cites W1585306115 @default.
• W2076255384 cites W1605758816 @default.
• W2076255384 cites W1607671357 @default.
• W2076255384 cites W1795056021 @default.
• W2076255384 cites W1821277660 @default.
• W2076255384 cites W1891964745 @default.
• W2076255384 cites W1937172266 @default.
• W2076255384 cites W1964700296 @default.
• W2076255384 cites W1965222236 @default.
• W2076255384 cites W1967455040 @default.
• W2076255384 cites W1970554113 @default.
• W2076255384 cites W1973300115 @default.
• W2076255384 cites W1984332535 @default.
• W2076255384 cites W1990425248 @default.
• W2076255384 cites W1999903313 @default.
• W2076255384 cites W2000965799 @default.
• W2076255384 cites W2005416074 @default.
• W2076255384 cites W2006376420 @default.
• W2076255384 cites W2012232655 @default.
• W2076255384 cites W2014770336 @default.
• W2076255384 cites W2015320012 @default.
• W2076255384 cites W2019438547 @default.
• W2076255384 cites W2029174334 @default.
• W2076255384 cites W2029381805 @default.
• W2076255384 cites W2034642104 @default.
• W2076255384 cites W2036966579 @default.
• W2076255384 cites W2045441934 @default.
• W2076255384 cites W2046430129 @default.
• W2076255384 cites W2047066026 @default.
• W2076255384 cites W2048781554 @default.
• W2076255384 cites W2049134173 @default.
• W2076255384 cites W2052896373 @default.
• W2076255384 cites W2056546622 @default.
• W2076255384 cites W2069786515 @default.
• W2076255384 cites W2085931606 @default.
• W2076255384 cites W2087840329 @default.
• W2076255384 cites W2091364041 @default.
• W2076255384 cites W2094019443 @default.
• W2076255384 cites W2095169768 @default.
• W2076255384 cites W2095535075 @default.
• W2076255384 cites W2105436298 @default.
• W2076255384 cites W2112059462 @default.
• W2076255384 cites W2115148022 @default.
• W2076255384 cites W2125403403 @default.
• W2076255384 cites W2126642279 @default.
• W2076255384 cites W2132802598 @default.
• W2076255384 cites W2135272731 @default.
• W2076255384 cites W2143656267 @default.
• W2076255384 cites W2158037543 @default.
• W2076255384 cites W2165818584 @default.
• W2076255384 cites W4240159045 @default.
• W2076255384 doi "https://doi.org/10.1007/s11068-008-9018-7" @default.
• W2076255384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3755592" @default.
• W2076255384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18392730" @default.
• W2076255384 hasPublicationYear "2006" @default.
• W2076255384 type Work @default.
• W2076255384 sameAs 2076255384 @default.
• W2076255384 citedByCount "9" @default.
• W2076255384 countsByYear W20762553842012 @default.
• W2076255384 countsByYear W20762553842013 @default.
• W2076255384 countsByYear W20762553842017 @default.
• W2076255384 countsByYear W20762553842018 @default.
• W2076255384 countsByYear W20762553842019 @default.
• W2076255384 countsByYear W20762553842022 @default.
• W2076255384 crossrefType "journal-article" @default.
• W2076255384 hasAuthorship W2076255384A5005573844 @default.
• W2076255384 hasAuthorship W2076255384A5030710357 @default.
• W2076255384 hasBestOaLocation W20762553842 @default.
• W2076255384 hasConcept C12554922 @default.
• W2076255384 hasConcept C153911025 @default.
• W2076255384 hasConcept C169760540 @default.
• W2076255384 hasConcept C184235292 @default.
• W2076255384 hasConcept C24998067 @default.
• W2076255384 hasConcept C28406088 @default.
• W2076255384 hasConcept C4141045 @default.
• W2076255384 hasConcept C55493867 @default.
• W2076255384 hasConcept C57074206 @default.
• W2076255384 hasConcept C62478195 @default.
• W2076255384 hasConcept C86803240 @default.
• W2076255384 hasConcept C95444343 @default.
• W2076255384 hasConcept C97029542 @default.
• W2076255384 hasConceptScore W2076255384C12554922 @default.
• W2076255384 hasConceptScore W2076255384C153911025 @default.
• W2076255384 hasConceptScore W2076255384C169760540 @default.
• W2076255384 hasConceptScore W2076255384C184235292 @default.
• W2076255384 hasConceptScore W2076255384C24998067 @default.
• W2076255384 hasConceptScore W2076255384C28406088 @default.
• W2076255384 hasConceptScore W2076255384C4141045 @default.

• next