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- W2076258597 abstract "The crucial role for CD28, its homolog CTLA-4 and their binding partners B7-1 and B7-2 in the generation of effective T-cell responses has been well documented. Recently, two new pairs of the CD28/B7 families were identified. The ability of these molecules to regulate T-cell expansion and effector function and the dynamic integration of the co-stimulatory and T-cell receptor signals are just beginning to be explored. Understanding these processes will be crucial for designing clinically relevant approaches to manipulate the adaptive immune system." @default.
- W2076258597 created "2016-06-24" @default.
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- W2076258597 date "2001-04-01" @default.
- W2076258597 modified "2023-10-18" @default.
- W2076258597 title "The expanding world of co-stimulation: the two-signal model revisited" @default.
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- W2076258597 doi "https://doi.org/10.1016/s1471-4906(01)01868-3" @default.
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