FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076264247> ?p ?o ?g. }

• W2076264247 abstract "Abstract Two inhibitors of Aedes aegypti trypsin have been purified from bovine serum and characterized. Inhibitor I has a molecular weight of about 43,500 and inhibitor II has a very high molecular weight (possibly about 1,000,000). They are located electrophoretically in association with the α1- and the α2-globulin fractions of serum respectively. Stoichiometric measurements indicate that the molar ratios of trypsin-inhibitor I and trypsin-inhibitor II complexes are 3.5 and 1.7 respectively. The Hill plot indicates that 2 molecules of inhibitor (inhibitor I or inhibitor II) inactivate 1 enzymic site of trypsin. In vitro, the formation of trypsin-inhibitor II complex has been demonstrated by Sephadex gel filtration and cellulose acetate electrophoresis. The complex retains most of its esterolytic activity but has a very low proteolytic activity. The esterolytic activity of the trypsin-inhibitor II complex is not inhibited by inhibitor I, soybean trypsin inhibitor, or phenylmethanesulphonyl fluoride (PMSF). The free trypsin esterolytic activity is inhibited by these substances. The complex has a lower Km than the free trypsin, but both have a similar pH optimum. Inhibitors I and II competitively inhibit the tryptic hydrolysis of denatured bovine haemoglobin. These two inhibitors and whole bovine serum non-competitively inhibit the tryptic hydrolysis of α-N- Benzoyl- dl -arginine -p- nitroanilide HCl (BAPNA) at 37°C. The mechanism of trypsin inhibition has been discussed from the aspect of the types of inhibition, and the thermo-dynamic parameters of the enzyme-inhibitor and the enzyme-substrate complexes." @default.
• W2076264247 created "2016-06-24" @default.
• W2076264247 creator A5001735273 @default.
• W2076264247 date "1971-06-01" @default.
• W2076264247 modified "2023-09-27" @default.
• W2076264247 title "The interactions of Aedes aegypti (L.) trypsin with its two inhibitors found in bovine serum" @default.
• W2076264247 cites W107696360 @default.
• W2076264247 cites W141227727 @default.
• W2076264247 cites W149169367 @default.
• W2076264247 cites W1516822956 @default.
• W2076264247 cites W1593417458 @default.
• W2076264247 cites W1750773183 @default.
• W2076264247 cites W1775749144 @default.
• W2076264247 cites W1963933978 @default.
• W2076264247 cites W1965614857 @default.
• W2076264247 cites W1966266212 @default.
• W2076264247 cites W1972865129 @default.
• W2076264247 cites W1977795980 @default.
• W2076264247 cites W1980235078 @default.
• W2076264247 cites W1982833680 @default.
• W2076264247 cites W1985458533 @default.
• W2076264247 cites W1985973796 @default.
• W2076264247 cites W1987107783 @default.
• W2076264247 cites W1989490708 @default.
• W2076264247 cites W1991648689 @default.
• W2076264247 cites W2000870026 @default.
• W2076264247 cites W2003806091 @default.
• W2076264247 cites W2006414606 @default.
• W2076264247 cites W2008538471 @default.
• W2076264247 cites W2015381079 @default.
• W2076264247 cites W2019524205 @default.
• W2076264247 cites W2026349299 @default.
• W2076264247 cites W2028891430 @default.
• W2076264247 cites W2035416775 @default.
• W2076264247 cites W2038623001 @default.
• W2076264247 cites W2047676959 @default.
• W2076264247 cites W2056744131 @default.
• W2076264247 cites W2067568333 @default.
• W2076264247 cites W2069574166 @default.
• W2076264247 cites W2073686932 @default.
• W2076264247 cites W2075907637 @default.
• W2076264247 cites W2087419767 @default.
• W2076264247 cites W2095052109 @default.
• W2076264247 cites W2317320980 @default.
• W2076264247 cites W2323836202 @default.
• W2076264247 cites W2325420932 @default.
• W2076264247 cites W2326454471 @default.
• W2076264247 cites W2334720602 @default.
• W2076264247 cites W2341186912 @default.
• W2076264247 cites W2418217845 @default.
• W2076264247 cites W2614999422 @default.
• W2076264247 cites W294028151 @default.
• W2076264247 cites W82555276 @default.
• W2076264247 doi "https://doi.org/10.1016/0020-1790(71)90074-6" @default.
• W2076264247 hasPublicationYear "1971" @default.
• W2076264247 type Work @default.
• W2076264247 sameAs 2076264247 @default.
• W2076264247 citedByCount "15" @default.
• W2076264247 crossrefType "journal-article" @default.
• W2076264247 hasAuthorship W2076264247A5001735273 @default.
• W2076264247 hasConcept C141814087 @default.
• W2076264247 hasConcept C163994747 @default.
• W2076264247 hasConcept C181199279 @default.
• W2076264247 hasConcept C185592680 @default.
• W2076264247 hasConcept C193363816 @default.
• W2076264247 hasConcept C2776351012 @default.
• W2076264247 hasConcept C2776980637 @default.
• W2076264247 hasConcept C2779288520 @default.
• W2076264247 hasConcept C2780340462 @default.
• W2076264247 hasConcept C43617362 @default.
• W2076264247 hasConcept C55493867 @default.
• W2076264247 hasConcept C94412978 @default.
• W2076264247 hasConceptScore W2076264247C141814087 @default.
• W2076264247 hasConceptScore W2076264247C163994747 @default.
• W2076264247 hasConceptScore W2076264247C181199279 @default.
• W2076264247 hasConceptScore W2076264247C185592680 @default.
• W2076264247 hasConceptScore W2076264247C193363816 @default.
• W2076264247 hasConceptScore W2076264247C2776351012 @default.
• W2076264247 hasConceptScore W2076264247C2776980637 @default.
• W2076264247 hasConceptScore W2076264247C2779288520 @default.
• W2076264247 hasConceptScore W2076264247C2780340462 @default.
• W2076264247 hasConceptScore W2076264247C43617362 @default.
• W2076264247 hasConceptScore W2076264247C55493867 @default.
• W2076264247 hasConceptScore W2076264247C94412978 @default.
• W2076264247 hasLocation W20762642471 @default.
• W2076264247 hasOpenAccess W2076264247 @default.
• W2076264247 hasPrimaryLocation W20762642471 @default.
• W2076264247 hasRelatedWork W1545107280 @default.
• W2076264247 hasRelatedWork W1575506960 @default.
• W2076264247 hasRelatedWork W1815051856 @default.
• W2076264247 hasRelatedWork W1972642896 @default.
• W2076264247 hasRelatedWork W1976299106 @default.
• W2076264247 hasRelatedWork W1992656031 @default.
• W2076264247 hasRelatedWork W2003026263 @default.
• W2076264247 hasRelatedWork W2024002150 @default.
• W2076264247 hasRelatedWork W2036862081 @default.
• W2076264247 hasRelatedWork W2060608975 @default.
• W2076264247 hasRelatedWork W2065835149 @default.
• W2076264247 hasRelatedWork W2067568333 @default.
• W2076264247 hasRelatedWork W2068456486 @default.

• next