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- W2076265692 abstract "Ultrasound contrast agents (UCA) micro-bubbles have been well recognized as a potential noninvasive tool for blood pressure estimation. However, previous UCA indices, e.g., the shift of the resonance frequency, echo amplitude and the disappearance time, suffered from problems of low resolution, nonlinearity in the relationship with blood pressure, and only variations of the local pressure but the absolute values etc. In this paper, the effect of ambient pressure on UCA sub-harmonic optimal driving frequency (SODF) was investigated, at which the sub-harmonic scattering signals were the maximum. By applying transmit frequencies between 3MHz and 8MHz and the acoustic pressure of 300kPa, the acoustic attenuation and scattering of micro-bubbles were measured at overpressures of 4mmHg, 50mmHg and 100mmHg, comparable with the healthy human blood pressure. For groups of micro-bubbles with 80% in the diameter range of 1-2 micrometers, the shift of the SODF (SSODF) was 0.6MHz between over-pressures of 4mmHg and 100mmHg, which was approximately twice of the corresponding shift of the resonance frequency, thus had an improved sensitivity of pressure estimation. The SSODF of UCA micro-bubbles may be as a novel and sensitive index of the local blood pressure estimation." @default.
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- W2076265692 date "2012-04-01" @default.
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- W2076265692 title "Dependence of the subharmonic signal from ultrasound contrast microbubbles on ambient pressure" @default.
- W2076265692 doi "https://doi.org/10.1121/1.4708438" @default.
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