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• W2076270117 abstract "Twenty-two patients with chronic lymphatic leukemia were studied clinically, hematologically and immunologically. The following immunologic tests were performed: serum electrophoresis, isohemagglutinins, response to typhoid-paratyphoid vaccination and to tuberculin, mumps and C. albicans skin tests, complement and properdin titers, and determination of serum macroglobulins. The patients were divided into two groups according to their history of infectious disease. Patients with chronic lymphatic leukemia who had frequent infectious complications could, in general, be distinguished by their lower serum gamma globulin levels. None of the other parameters considered allowed us to differentiate between the two groups. No relationship was found between duration of disease and hypogammaglobulinemia in this series, but there was some indication that hypogammaglobulinemia was a late stage in the natural history of chronic lymphatic leukemia. The various serum protein abnormalities which may characterize patients with this disease suggest that despite morphologic similarities there may be more than one kind of chronic lymphatic leukemia." @default.
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• W2076270117 date "1961-11-01" @default.
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• W2076270117 title "Immunologic factors and resistance to infection in chronic lymphatic leukemia" @default.
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• W2076270117 doi "https://doi.org/10.1016/0002-9343(61)90159-0" @default.
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