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• W2076272008 startingPage "925" @default.
• W2076272008 abstract "Cytochrome P450 (P450) is the superfamily of enzymes responsible for biotransformation of endobiotics and xenobiotics. However, their large isoform multiplicity, inducibility, diverse structure, widespread distribution, polymorphic expression, and broad overlapping substrate specificity make it difficult to measure the precise role of each individual P450 to the metabolism of drugs (or carcinogens) and hamper the understanding of the relationship between the genetic/environmental factors that regulate P450 phenotype and the responses of the individual P450s to drugs. The antibodies against P450s have been useful tools for the quantitative determination of expression level and contribution of the epitope-specific P450 to the metabolism of a drug or carcinogen substrate in tissues containing multiple P450 isoforms and for implications in pharmacogenetics and human risk assessment. In particular, the inhibitory antibodies are uniquely suited for reaction phenotyping that helps to predict human pharmacokinetics for clinical drug-drug interaction potential in drug discovery and development." @default.
• W2076272008 created "2016-06-24" @default.
• W2076272008 creator A5023584195 @default.
• W2076272008 creator A5075729159 @default.
• W2076272008 date "2009-02-05" @default.
• W2076272008 modified "2023-09-29" @default.
• W2076272008 title "Antibodies as a Probe in Cytochrome P450 Research" @default.
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• W2076272008 doi "https://doi.org/10.1124/dmd.108.025718" @default.
• W2076272008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19196844" @default.
• W2076272008 hasPublicationYear "2009" @default.
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