Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076272210> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2076272210 endingPage "697" @default.
- W2076272210 startingPage "691" @default.
- W2076272210 abstract "A rapid, sensitive and specific liquid chromatography-electrospray-tandem mass spectrometric (LC-ESI-MS/MS) method for the simultaneous detection and quantitation of methylprednisolone acetate (MPA) and methylprednisolone (MP) in rat plasma, using a triple-stage quadrupole, has been developed and validated. MP-D(2) was used as internal standard (IS) and acetonitrile was added to plasma samples for protein precipitation. After extraction with dichloromethane, the analytes were separated on a C-12 reversed-phase column by isocratic elution (6min at a flow rate 0.2mLmin(-1)) with water containing 0.01% formic acid (A) and acetonitrile (B) (50:50, v/v). Quantitation was performed in positive ion multiple reaction monitoring (MRM) mode by applying the following precursor-to-product ion transitions: MPA m/z 417-->135+161+253; MP m/z 375-->135+161+253; IS m/z 377-->135+161+253. The method, validated over the concentration range 6-600ngmL(-1), has been shown to meet the current requirements of bioananalytical validation, providing satisfactory results in terms of linearity, recovery, intra-day and inter-day precision and accuracy. The lower limit of quantitation (LLOQ) was 6ngmL(-1) for both the analytes (0.080 and 0.072pmol injected for MP and MPA, respectively). The method was successfully applied to monitor the plasma levels of MPA and MP following intra-articular (IA) injections of a low MPA (Depo-Medrol((R))) dose in rats." @default.
- W2076272210 created "2016-06-24" @default.
- W2076272210 creator A5019484257 @default.
- W2076272210 creator A5075487715 @default.
- W2076272210 creator A5080240411 @default.
- W2076272210 creator A5090581943 @default.
- W2076272210 date "2010-02-01" @default.
- W2076272210 modified "2023-10-06" @default.
- W2076272210 title "A rapid and sensitive LC–ESI-MS/MS method for detection and quantitation of methylprednisolone and methylprednisolone acetate in rat plasma after intra-articular administration" @default.
- W2076272210 cites W1925599086 @default.
- W2076272210 cites W1978752106 @default.
- W2076272210 cites W1980908338 @default.
- W2076272210 cites W1984317348 @default.
- W2076272210 cites W1990692609 @default.
- W2076272210 cites W2016037150 @default.
- W2076272210 cites W2017031083 @default.
- W2076272210 cites W2033795915 @default.
- W2076272210 cites W2035632960 @default.
- W2076272210 cites W2037139145 @default.
- W2076272210 cites W2040982724 @default.
- W2076272210 cites W2045779362 @default.
- W2076272210 cites W2047605361 @default.
- W2076272210 cites W2050667886 @default.
- W2076272210 cites W2068095447 @default.
- W2076272210 cites W2086815364 @default.
- W2076272210 cites W2092198330 @default.
- W2076272210 cites W2134050939 @default.
- W2076272210 cites W2140094674 @default.
- W2076272210 cites W2170277712 @default.
- W2076272210 cites W2171767061 @default.
- W2076272210 doi "https://doi.org/10.1016/j.jpba.2009.09.041" @default.
- W2076272210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19875262" @default.
- W2076272210 hasPublicationYear "2010" @default.
- W2076272210 type Work @default.
- W2076272210 sameAs 2076272210 @default.
- W2076272210 citedByCount "14" @default.
- W2076272210 countsByYear W20762722102012 @default.
- W2076272210 countsByYear W20762722102013 @default.
- W2076272210 countsByYear W20762722102016 @default.
- W2076272210 countsByYear W20762722102017 @default.
- W2076272210 countsByYear W20762722102018 @default.
- W2076272210 countsByYear W20762722102021 @default.
- W2076272210 countsByYear W20762722102022 @default.
- W2076272210 countsByYear W20762722102023 @default.
- W2076272210 crossrefType "journal-article" @default.
- W2076272210 hasAuthorship W2076272210A5019484257 @default.
- W2076272210 hasAuthorship W2076272210A5075487715 @default.
- W2076272210 hasAuthorship W2076272210A5080240411 @default.
- W2076272210 hasAuthorship W2076272210A5090581943 @default.
- W2076272210 hasConcept C10390740 @default.
- W2076272210 hasConcept C119128265 @default.
- W2076272210 hasConcept C162356407 @default.
- W2076272210 hasConcept C172493649 @default.
- W2076272210 hasConcept C185592680 @default.
- W2076272210 hasConcept C194451485 @default.
- W2076272210 hasConcept C2777379063 @default.
- W2076272210 hasConcept C31827203 @default.
- W2076272210 hasConcept C43617362 @default.
- W2076272210 hasConcept C71043704 @default.
- W2076272210 hasConcept C74774607 @default.
- W2076272210 hasConceptScore W2076272210C10390740 @default.
- W2076272210 hasConceptScore W2076272210C119128265 @default.
- W2076272210 hasConceptScore W2076272210C162356407 @default.
- W2076272210 hasConceptScore W2076272210C172493649 @default.
- W2076272210 hasConceptScore W2076272210C185592680 @default.
- W2076272210 hasConceptScore W2076272210C194451485 @default.
- W2076272210 hasConceptScore W2076272210C2777379063 @default.
- W2076272210 hasConceptScore W2076272210C31827203 @default.
- W2076272210 hasConceptScore W2076272210C43617362 @default.
- W2076272210 hasConceptScore W2076272210C71043704 @default.
- W2076272210 hasConceptScore W2076272210C74774607 @default.
- W2076272210 hasIssue "3" @default.
- W2076272210 hasLocation W20762722101 @default.
- W2076272210 hasLocation W20762722102 @default.
- W2076272210 hasOpenAccess W2076272210 @default.
- W2076272210 hasPrimaryLocation W20762722101 @default.
- W2076272210 hasRelatedWork W1998032538 @default.
- W2076272210 hasRelatedWork W2484326582 @default.
- W2076272210 hasRelatedWork W2795477932 @default.
- W2076272210 hasRelatedWork W2800973557 @default.
- W2076272210 hasRelatedWork W2970391062 @default.
- W2076272210 hasRelatedWork W2973860202 @default.
- W2076272210 hasRelatedWork W2995228982 @default.
- W2076272210 hasRelatedWork W3046410380 @default.
- W2076272210 hasRelatedWork W3087792627 @default.
- W2076272210 hasRelatedWork W4283319477 @default.
- W2076272210 hasVolume "51" @default.
- W2076272210 isParatext "false" @default.
- W2076272210 isRetracted "false" @default.
- W2076272210 magId "2076272210" @default.
- W2076272210 workType "article" @default.