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- W2076277763 abstract "Human soluble Fas ligand (sFasL) has an apoptotic activity in contrast to murine sFasL. The physiological function of human sFasL is not known, while the pathological consequence of sFasL overproduction has been reported. To understand the physiological function of (human) sFasL, murine and human lymphocytes were treated with sFasL. sFasL treatment significantly decreased CD45RBlo memory CD4+ lymphocyte fraction and increased propidium iodide (PI)+ apoptotic CD45RBloCD4+ lymphocytes among murine peripheral lymphocytes. However, sFasL treatment neither decreased CD45RO+ memory CD4+ lymphocyte fraction nor increased PI+ CD45RO+CD4+ lymphocytes among human peripheral lymphocytes, suggesting that the deletion of memory cells by sFasL had already occurred in vivo. Patients with systemic lupus erythematosus had sFasL-susceptible memory cell fraction suggesting an incomplete deletion of such memory cells. These results suggest that the physiological function of human sFasL is to delete the potentially auto-reactive memory lymphocytes, which complements membrane FasL (mFasL)-mediated deletion of auto-reactive cells in human beings but not in mice." @default.
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- W2076277763 date "2002-01-01" @default.
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- W2076277763 title "Soluble Fas Ligand-susceptible Memory Cells in Mice but Not in Human: Potential Role of Soluble Fas Ligand in Deletion of Auto-reactive Cells" @default.
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- W2076277763 doi "https://doi.org/10.1080/08916930290005882" @default.
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