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- W2076278159 abstract "Summary The inotropic effect of ouabain was studied in vitro on different rat and guinea-pig heart preparations, either spontaneously beating or driven at different frequencies. In guinea-pigs, ouabain has a positive inotropic effect on spontaneously beating atria and on ventricle strips at various frequencies of driving; it has a more limited effect on the left atrium, driven at low frequency. In rats, ouabain has a positive inotropic effect only on ventricle strips driven at 1 Hz. We suggest that the absence of activity of ouabain on rat heart preparations spontaneously beating or driven at high frequency is due to the fact that in these conditions calcium exchange is already maximal and so cannot be further increased by cardiac glycosides." @default.
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- W2076278159 date "1982-09-01" @default.
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- W2076278159 title "Further studies on the frequency-dependent inotropic effect of ouabain on mammalian cardiac muscle" @default.
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- W2076278159 doi "https://doi.org/10.1016/s0031-6989(82)80078-7" @default.
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