FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076280169> ?p ?o ?g. }

• W2076280169 endingPage "1628" @default.
• W2076280169 startingPage "1620" @default.
• W2076280169 abstract "The capacity of brain to dephosphorylate glucose-6-phosphate has been established, but the magnitude and significance of this capacity in vivo are debated, particularly in regard to dephosphorylation of the glucose analog 2-deoxyglucose. We now report results of external measurement in the brains of conscious rats with simultaneous resolution and quantification of both 2-deoxyglucose and its phosphorylated product by nuclear magnetic resonance (NMR) techniques that used 2-[6-13]deoxyglucose together with proton-decoupled 13C surface-coil spectroscopy. As NMR techniques require large doses of 2-deoxyglucose, a dose comparison was first made using decay curves of total label after tracer doses of 2-[14C]deoxyglucose without versus with unlabeled deoxyglucose at 500 mg/kg (the NMR dose). Similar cerebral half-lives for the two doses were found, and no behavioral evidence for toxicity of the NMR dose was seen. In vivo NMR monitoring of conscious rats showed that the analog reached maximal cerebral concentration within 10 min of the intravenous bolus and decayed with a half-life of 29 +/- 7 min (n = 4; mean +/- SEM), whereas 2-deoxyglucose-6-phosphate reached peak concentration between 30 and 40 min and decayed with a half-life of 2.1 +/- 0.3 h, equivalent to a fractional loss of 0.8%/min. Thirty-one percent (+/- 5%) of the total analog pool (which showed a half-life of 1.4 h) consisted of 2-deoxyglucose at 45 min after the bolus. The results support an active but limited role for dephosphorylation by normal brain in glucose analog (and potentially glucose) metabolism in the unstimulated conscious rat and a wide concentration range for the metabolic operations involved." @default.
• W2076280169 created "2016-06-24" @default.
• W2076280169 creator A5017653267 @default.
• W2076280169 creator A5047564461 @default.
• W2076280169 creator A5061044767 @default.
• W2076280169 creator A5067489810 @default.
• W2076280169 date "1989-11-01" @default.
• W2076280169 modified "2023-10-16" @default.
• W2076280169 title "Simultaneous In Vivb Monitoring of Cerebral Deoxyglucose and Deoxyglucos-6-Phosphate by^l3C{^lH} Nuclear Magnetic Resonance Spectroscopy" @default.
• W2076280169 cites W1503075767 @default.
• W2076280169 cites W1565787013 @default.
• W2076280169 cites W1603818945 @default.
• W2076280169 cites W1965869420 @default.
• W2076280169 cites W1966679042 @default.
• W2076280169 cites W1977923285 @default.
• W2076280169 cites W1980283468 @default.
• W2076280169 cites W1985139870 @default.
• W2076280169 cites W1985455753 @default.
• W2076280169 cites W1985849136 @default.
• W2076280169 cites W1999581124 @default.
• W2076280169 cites W2000588414 @default.
• W2076280169 cites W2008871335 @default.
• W2076280169 cites W2014381517 @default.
• W2076280169 cites W2017682376 @default.
• W2076280169 cites W2018627425 @default.
• W2076280169 cites W2019236950 @default.
• W2076280169 cites W2020950334 @default.
• W2076280169 cites W2026872374 @default.
• W2076280169 cites W2035737248 @default.
• W2076280169 cites W2043516265 @default.
• W2076280169 cites W2044277049 @default.
• W2076280169 cites W2048283588 @default.
• W2076280169 cites W2054111304 @default.
• W2076280169 cites W2061496400 @default.
• W2076280169 cites W2064141136 @default.
• W2076280169 cites W2067981725 @default.
• W2076280169 cites W2070087106 @default.
• W2076280169 cites W2070881094 @default.
• W2076280169 cites W2081892166 @default.
• W2076280169 cites W2084931568 @default.
• W2076280169 cites W2090203522 @default.
• W2076280169 cites W2090306035 @default.
• W2076280169 cites W2091601007 @default.
• W2076280169 cites W2113997654 @default.
• W2076280169 cites W2117788447 @default.
• W2076280169 cites W2118672167 @default.
• W2076280169 cites W2140375496 @default.
• W2076280169 cites W72552930 @default.
• W2076280169 doi "https://doi.org/10.1111/j.1471-4159.1989.tb08560.x" @default.
• W2076280169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2795021" @default.
• W2076280169 hasPublicationYear "1989" @default.
• W2076280169 type Work @default.
• W2076280169 sameAs 2076280169 @default.
• W2076280169 citedByCount "20" @default.
• W2076280169 countsByYear W20762801692013 @default.
• W2076280169 countsByYear W20762801692014 @default.
• W2076280169 countsByYear W20762801692015 @default.
• W2076280169 countsByYear W20762801692016 @default.
• W2076280169 countsByYear W20762801692019 @default.
• W2076280169 crossrefType "journal-article" @default.
• W2076280169 hasAuthorship W2076280169A5017653267 @default.
• W2076280169 hasAuthorship W2076280169A5047564461 @default.
• W2076280169 hasAuthorship W2076280169A5061044767 @default.
• W2076280169 hasAuthorship W2076280169A5067489810 @default.
• W2076280169 hasConcept C11960822 @default.
• W2076280169 hasConcept C121332964 @default.
• W2076280169 hasConcept C150903083 @default.
• W2076280169 hasConcept C177322064 @default.
• W2076280169 hasConcept C178666793 @default.
• W2076280169 hasConcept C181912034 @default.
• W2076280169 hasConcept C185592680 @default.
• W2076280169 hasConcept C207001950 @default.
• W2076280169 hasConcept C2777132085 @default.
• W2076280169 hasConcept C2777739839 @default.
• W2076280169 hasConcept C2780909259 @default.
• W2076280169 hasConcept C2989005 @default.
• W2076280169 hasConcept C2992907065 @default.
• W2076280169 hasConcept C46141821 @default.
• W2076280169 hasConcept C55493867 @default.
• W2076280169 hasConcept C66974803 @default.
• W2076280169 hasConcept C71240020 @default.
• W2076280169 hasConcept C71924100 @default.
• W2076280169 hasConcept C86803240 @default.
• W2076280169 hasConceptScore W2076280169C11960822 @default.
• W2076280169 hasConceptScore W2076280169C121332964 @default.
• W2076280169 hasConceptScore W2076280169C150903083 @default.
• W2076280169 hasConceptScore W2076280169C177322064 @default.
• W2076280169 hasConceptScore W2076280169C178666793 @default.
• W2076280169 hasConceptScore W2076280169C181912034 @default.
• W2076280169 hasConceptScore W2076280169C185592680 @default.
• W2076280169 hasConceptScore W2076280169C207001950 @default.
• W2076280169 hasConceptScore W2076280169C2777132085 @default.
• W2076280169 hasConceptScore W2076280169C2777739839 @default.
• W2076280169 hasConceptScore W2076280169C2780909259 @default.
• W2076280169 hasConceptScore W2076280169C2989005 @default.
• W2076280169 hasConceptScore W2076280169C2992907065 @default.
• W2076280169 hasConceptScore W2076280169C46141821 @default.
• W2076280169 hasConceptScore W2076280169C55493867 @default.

• next