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• W2076285445 endingPage "52" @default.
• W2076285445 startingPage "41" @default.
• W2076285445 abstract "The transcription factor c-Fos has surface thermodynamic properties that allow it to differentially interact with phospholipids, especially PIP2. It regulates phospholipid metabolism both in vivo and in vitro, and modulates degradation of phospholipid monolayers by phospholipases in a way that depends on the membrane intermolecular packing (i.e., surface lateral pressure). With the aim to understand details of the interactions of c-Fos at the membrane level, we studied the surface packing, dipole potential, compressibility and topography of mixed films of the protein with PIP2. We show that c-Fos changes the packing of liquid-expanded PIP2 monolayers, in a different manner with respect to its effect on the similarly liquid-expanded dilauroylphosphatidylcholine monolayers. The changes at the local molecular level are transduced to long-range inhomogeneities of the surface, detected by Brewster angle (BAM) and epifluorescence microscopy (EFM). Our results highlight the capacity of c-Fos to alter the packing and dipole potential of the lipid-protein interface. This involves variations of the surface in-plane elasticity and lateral segregation of phase domains. These dynamic, reversible alterations of surface organization provide a basis by which c-Fos may transduce molecular information at the membrane level." @default.
• W2076285445 created "2016-06-24" @default.
• W2076285445 creator A5041093258 @default.
• W2076285445 creator A5059350404 @default.
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• W2076285445 date "2005-02-01" @default.
• W2076285445 modified "2023-10-09" @default.
• W2076285445 title "c-Fos and phosphatidylinositol-4,5-bisphosphate reciprocally reorganize in mixed monolayers" @default.
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• W2076285445 doi "https://doi.org/10.1016/j.bbamem.2004.11.007" @default.
• W2076285445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15670730" @default.
• W2076285445 hasPublicationYear "2005" @default.
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