Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076286033> ?p ?o ?g. }
- W2076286033 endingPage "222" @default.
- W2076286033 startingPage "213" @default.
- W2076286033 abstract "To address the role of glycosylation on fibrillogenicity of amyloidogenic chicken cystatin, the consensus sequence for N-linked glycosylation (Asn106-Ile108 --> Asn106-Thr108) was introduced by site-directed mutagenesis into the wild-type and amyloidogenic chicken cystatins to construct the glycosylated form of chicken cystatins. Both the glycosylated and unglycosylated forms of wild-type and amyloidogenic mutant I66Q cystatin were expressed and secreted in a culture medium of yeast Pichia pastoris transformants. Comparison of the amount of insoluble aggregate, the secondary structure, and fibrillogenicity has shown that the N-linked glycosylation could prevent amyloid fibril formation of amyloidogenic chicken cystatin secreted in yeast cells without affecting its inhibitory activities. Further study showed this glycosylation could inhibit the formation of cystatin dimers. Therefore, our data strongly suggested that the mechanism causing the prevention of amyloidogenic cystation fibril formation may be realized through suppression of the formation of three-dimensional domain-swapped dimers and oligomers of amyloidogenic cystatin by the glycosylated chains at position 106." @default.
- W2076286033 created "2016-06-24" @default.
- W2076286033 creator A5076976935 @default.
- W2076286033 date "2006-02-01" @default.
- W2076286033 modified "2023-10-13" @default.
- W2076286033 title "Prevention of amyloid fibril formation of amyloidogenic chicken cystatin by site-specific glycosylation in yeast" @default.
- W2076286033 cites W118192089 @default.
- W2076286033 cites W1482870101 @default.
- W2076286033 cites W148771838 @default.
- W2076286033 cites W1496215511 @default.
- W2076286033 cites W1502392336 @default.
- W2076286033 cites W1588296570 @default.
- W2076286033 cites W1860073488 @default.
- W2076286033 cites W1970232844 @default.
- W2076286033 cites W1971509947 @default.
- W2076286033 cites W1973103437 @default.
- W2076286033 cites W1973897761 @default.
- W2076286033 cites W1974187431 @default.
- W2076286033 cites W1978322999 @default.
- W2076286033 cites W1985388329 @default.
- W2076286033 cites W2003707792 @default.
- W2076286033 cites W2004398176 @default.
- W2076286033 cites W2010241698 @default.
- W2076286033 cites W2012455318 @default.
- W2076286033 cites W2013900111 @default.
- W2076286033 cites W2018289835 @default.
- W2076286033 cites W2018716326 @default.
- W2076286033 cites W2030886065 @default.
- W2076286033 cites W2045893780 @default.
- W2076286033 cites W2047841570 @default.
- W2076286033 cites W2048469936 @default.
- W2076286033 cites W2068528390 @default.
- W2076286033 cites W2068936080 @default.
- W2076286033 cites W2072221843 @default.
- W2076286033 cites W2074818088 @default.
- W2076286033 cites W2075260637 @default.
- W2076286033 cites W2079893739 @default.
- W2076286033 cites W2086740068 @default.
- W2076286033 cites W2090311725 @default.
- W2076286033 cites W2090560276 @default.
- W2076286033 cites W2090771452 @default.
- W2076286033 cites W2100837269 @default.
- W2076286033 cites W2126254912 @default.
- W2076286033 cites W2128971912 @default.
- W2076286033 cites W2152477899 @default.
- W2076286033 cites W2158783623 @default.
- W2076286033 cites W2159391891 @default.
- W2076286033 cites W2161933333 @default.
- W2076286033 cites W2315772837 @default.
- W2076286033 cites W2769999982 @default.
- W2076286033 cites W4237446424 @default.
- W2076286033 doi "https://doi.org/10.1110/ps.051753306" @default.
- W2076286033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2242452" @default.
- W2076286033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16434741" @default.
- W2076286033 hasPublicationYear "2006" @default.
- W2076286033 type Work @default.
- W2076286033 sameAs 2076286033 @default.
- W2076286033 citedByCount "15" @default.
- W2076286033 countsByYear W20762860332012 @default.
- W2076286033 countsByYear W20762860332013 @default.
- W2076286033 countsByYear W20762860332015 @default.
- W2076286033 countsByYear W20762860332016 @default.
- W2076286033 countsByYear W20762860332019 @default.
- W2076286033 countsByYear W20762860332021 @default.
- W2076286033 countsByYear W20762860332022 @default.
- W2076286033 crossrefType "journal-article" @default.
- W2076286033 hasAuthorship W2076286033A5076976935 @default.
- W2076286033 hasBestOaLocation W20762860332 @default.
- W2076286033 hasConcept C104317684 @default.
- W2076286033 hasConcept C108625454 @default.
- W2076286033 hasConcept C143065580 @default.
- W2076286033 hasConcept C159641895 @default.
- W2076286033 hasConcept C179104552 @default.
- W2076286033 hasConcept C185592680 @default.
- W2076286033 hasConcept C206212055 @default.
- W2076286033 hasConcept C2777313579 @default.
- W2076286033 hasConcept C2777633098 @default.
- W2076286033 hasConcept C2779222958 @default.
- W2076286033 hasConcept C2779548226 @default.
- W2076286033 hasConcept C2780412452 @default.
- W2076286033 hasConcept C2781372317 @default.
- W2076286033 hasConcept C30324644 @default.
- W2076286033 hasConcept C40767141 @default.
- W2076286033 hasConcept C55493867 @default.
- W2076286033 hasConceptScore W2076286033C104317684 @default.
- W2076286033 hasConceptScore W2076286033C108625454 @default.
- W2076286033 hasConceptScore W2076286033C143065580 @default.
- W2076286033 hasConceptScore W2076286033C159641895 @default.
- W2076286033 hasConceptScore W2076286033C179104552 @default.
- W2076286033 hasConceptScore W2076286033C185592680 @default.
- W2076286033 hasConceptScore W2076286033C206212055 @default.
- W2076286033 hasConceptScore W2076286033C2777313579 @default.
- W2076286033 hasConceptScore W2076286033C2777633098 @default.
- W2076286033 hasConceptScore W2076286033C2779222958 @default.
- W2076286033 hasConceptScore W2076286033C2779548226 @default.
- W2076286033 hasConceptScore W2076286033C2780412452 @default.
- W2076286033 hasConceptScore W2076286033C2781372317 @default.
- W2076286033 hasConceptScore W2076286033C30324644 @default.