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- W2076292040 endingPage "1076" @default.
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- W2076292040 abstract "Insulin-like growth factor I (IGF-I) was 3 times more potent in pagating MCF-7 cell proliferation than epidermal growth factor (EGF). IGF-I stimulated c-fos mRNA expression about 5 times less than EGF. Both growth factors were equipotent in inducing c-jun and c-myc mRNA expressions. The protein level of c-Myc correlated with the mRNA level. IGF-I and EGF stimulated the transcriptional activity dependent on the phorbol 12-myristate 13-acetate-responsive element (TRE) to the same extent, when measured by the chloramphenicol acetyl transferase activity of a transiently transfected multiple TRE construct. These results strongly indicate that the expression levels of the measured proto-oncogenes do not correlate with the increase of growth stimulation by IGF-I and EGF and are not growth rate limiting for the human MCF-7 breast cancer cells." @default.
- W2076292040 created "2016-06-24" @default.
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- W2076292040 date "1992-11-01" @default.
- W2076292040 modified "2023-10-12" @default.
- W2076292040 title "C-fos, C-jun and C-myc expressions are not growth rate limiting for the human MCF-7 breast cancer cells" @default.
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- W2076292040 doi "https://doi.org/10.1016/0006-291x(92)91340-v" @default.
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