FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076294712> ?p ?o ?g. }

• W2076294712 endingPage "109" @default.
• W2076294712 startingPage "99" @default.
• W2076294712 abstract "Primary cultures of sheep thyroid cells have been used to study regulation of thyroid growth and function by growth factors and TSH. Cells were plated at low density to minimize contributions from the endogenously produced insulin-like growth factors and their binding proteins and other proteins or hormones secreted by thyroid cells in culture. Growth of the cells was followed for 7-11 days in medium without serum. We found that TSH by itself was unable to stimulate thyroid growth. However, the ability of insulin and IGF-I to stimulate thyroid cell growth was markedly potentiated by TSH. Thyroid function was assayed by measurement of uptake of pertechnetate and organification of iodide and also by synthesis of thyroglobulin mRNA. TSH alone was unable to stimulate thyroid function appreciably. Insulin and IGF-I were ineffective by themselves at stimulating thyroid differentiated function, but in the presence of TSH, all indices were stimulated markedly. We conclude that TSH by itself is not a growth factor for thyroid cells. However, in the presence of insulin or IGF-I, TSH potentiates the growth-stimulating properties of this hormone. Similarly, TSH by itself does not stimulate thyroid function but requires the presence of insulin or IGF-I. These data show the cooperative interactions between growth factors and TSH in regulating both thyroid growth and function." @default.
• W2076294712 created "2016-06-24" @default.
• W2076294712 creator A5003740962 @default.
• W2076294712 creator A5009389483 @default.
• W2076294712 creator A5050448142 @default.
• W2076294712 date "1990-01-01" @default.
• W2076294712 modified "2023-09-25" @default.
• W2076294712 title "Interaction of TSH, Insulin and Insulin-like Growth Factors in Regulating Thyroid Growth and Function" @default.
• W2076294712 cites W1510707687 @default.
• W2076294712 cites W1581884496 @default.
• W2076294712 cites W1974535035 @default.
• W2076294712 cites W1988803304 @default.
• W2076294712 cites W1990729455 @default.
• W2076294712 cites W1991183818 @default.
• W2076294712 cites W1997885037 @default.
• W2076294712 cites W2014669590 @default.
• W2076294712 cites W2016096247 @default.
• W2076294712 cites W2031018763 @default.
• W2076294712 cites W2031588343 @default.
• W2076294712 cites W2032493713 @default.
• W2076294712 cites W2033844244 @default.
• W2076294712 cites W2042843602 @default.
• W2076294712 cites W2044090640 @default.
• W2076294712 cites W2048159338 @default.
• W2076294712 cites W2055109291 @default.
• W2076294712 cites W2059080130 @default.
• W2076294712 cites W2064757733 @default.
• W2076294712 cites W2073553245 @default.
• W2076294712 cites W2075969450 @default.
• W2076294712 cites W2080568630 @default.
• W2076294712 cites W2087823365 @default.
• W2076294712 cites W2090780998 @default.
• W2076294712 cites W2153563435 @default.
• W2076294712 doi "https://doi.org/10.3109/08977199009071497" @default.
• W2076294712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2160262" @default.
• W2076294712 hasPublicationYear "1990" @default.
• W2076294712 type Work @default.
• W2076294712 sameAs 2076294712 @default.
• W2076294712 citedByCount "88" @default.
• W2076294712 countsByYear W20762947122012 @default.
• W2076294712 countsByYear W20762947122013 @default.
• W2076294712 countsByYear W20762947122014 @default.
• W2076294712 countsByYear W20762947122015 @default.
• W2076294712 countsByYear W20762947122016 @default.
• W2076294712 countsByYear W20762947122017 @default.
• W2076294712 countsByYear W20762947122018 @default.
• W2076294712 countsByYear W20762947122019 @default.
• W2076294712 countsByYear W20762947122020 @default.
• W2076294712 countsByYear W20762947122021 @default.
• W2076294712 countsByYear W20762947122022 @default.
• W2076294712 countsByYear W20762947122023 @default.
• W2076294712 crossrefType "journal-article" @default.
• W2076294712 hasAuthorship W2076294712A5003740962 @default.
• W2076294712 hasAuthorship W2076294712A5009389483 @default.
• W2076294712 hasAuthorship W2076294712A5050448142 @default.
• W2076294712 hasConcept C126322002 @default.
• W2076294712 hasConcept C134018914 @default.
• W2076294712 hasConcept C170493617 @default.
• W2076294712 hasConcept C185592680 @default.
• W2076294712 hasConcept C2775960820 @default.
• W2076294712 hasConcept C2777886399 @default.
• W2076294712 hasConcept C2778835679 @default.
• W2076294712 hasConcept C2779123554 @default.
• W2076294712 hasConcept C2779306644 @default.
• W2076294712 hasConcept C2780689927 @default.
• W2076294712 hasConcept C2993291352 @default.
• W2076294712 hasConcept C526584372 @default.
• W2076294712 hasConcept C71315377 @default.
• W2076294712 hasConcept C71924100 @default.
• W2076294712 hasConcept C86803240 @default.
• W2076294712 hasConceptScore W2076294712C126322002 @default.
• W2076294712 hasConceptScore W2076294712C134018914 @default.
• W2076294712 hasConceptScore W2076294712C170493617 @default.
• W2076294712 hasConceptScore W2076294712C185592680 @default.
• W2076294712 hasConceptScore W2076294712C2775960820 @default.
• W2076294712 hasConceptScore W2076294712C2777886399 @default.
• W2076294712 hasConceptScore W2076294712C2778835679 @default.
• W2076294712 hasConceptScore W2076294712C2779123554 @default.
• W2076294712 hasConceptScore W2076294712C2779306644 @default.
• W2076294712 hasConceptScore W2076294712C2780689927 @default.
• W2076294712 hasConceptScore W2076294712C2993291352 @default.
• W2076294712 hasConceptScore W2076294712C526584372 @default.
• W2076294712 hasConceptScore W2076294712C71315377 @default.
• W2076294712 hasConceptScore W2076294712C71924100 @default.
• W2076294712 hasConceptScore W2076294712C86803240 @default.
• W2076294712 hasIssue "2" @default.
• W2076294712 hasLocation W20762947121 @default.
• W2076294712 hasLocation W20762947122 @default.
• W2076294712 hasOpenAccess W2076294712 @default.
• W2076294712 hasPrimaryLocation W20762947121 @default.
• W2076294712 hasRelatedWork W1972113515 @default.
• W2076294712 hasRelatedWork W1988955289 @default.
• W2076294712 hasRelatedWork W1989449228 @default.
• W2076294712 hasRelatedWork W2010645160 @default.
• W2076294712 hasRelatedWork W2089518257 @default.
• W2076294712 hasRelatedWork W2146710301 @default.
• W2076294712 hasRelatedWork W2155312245 @default.
• W2076294712 hasRelatedWork W2322571913 @default.

• next