FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076299286> ?p ?o ?g. }

• W2076299286 endingPage "12" @default.
• W2076299286 startingPage "1" @default.
• W2076299286 abstract "Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, by increasing expression of tumor-associated antigens. However, the impact of 5-Aza immune responses remains poorly understood. Here, T-cell mediated tumor immunity effects of 5-Aza, are investigated in vitro and in vivo . T-cells from healthy donors were treated with 5-Aza and analyzed by qRT-PCR and flow cytometry for changes in gene expression and phenotype. Functionality was assessed by a tumor lysis assay. Peripheral blood from patients treated with 5-Aza after alloSCT was monitored for changes in T-cell subpopulations. 5-Aza treatment resulted in a decrease in CD8+ T-cells, whereas CD4+ T-cells increased. Furthermore, numbers of IFN- γ + T-helper 1 cells (Th1) were reduced, while Treg-cells showed substantial increase. Additionally, CD8+ T-cells exhibited limited killing capacity against leukemic target cells. In vivo data confirm the increase of Treg compartment, while CD8+ T-effector cell numbers were reduced. 5-Aza treatment results in a shift from cytotoxic to regulatory T-cells with a functional phenotype and a major reduction in proinflammatory Th1-cells, indicating a strong inhibition of tumor-specific T-cell immunity by 5-Aza." @default.
• W2076299286 created "2016-06-24" @default.
• W2076299286 creator A5017637135 @default.
• W2076299286 creator A5028638344 @default.
• W2076299286 creator A5042722243 @default.
• W2076299286 creator A5043451583 @default.
• W2076299286 creator A5047913787 @default.
• W2076299286 creator A5050793635 @default.
• W2076299286 creator A5052933885 @default.
• W2076299286 creator A5086612276 @default.
• W2076299286 date "2014-01-01" @default.
• W2076299286 modified "2023-10-06" @default.
• W2076299286 title "5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity" @default.
• W2076299286 cites W1481521731 @default.
• W2076299286 cites W1534177339 @default.
• W2076299286 cites W1563453316 @default.
• W2076299286 cites W1633547128 @default.
• W2076299286 cites W1674079630 @default.
• W2076299286 cites W1796660362 @default.
• W2076299286 cites W1976856958 @default.
• W2076299286 cites W1977706798 @default.
• W2076299286 cites W1978529353 @default.
• W2076299286 cites W1989354231 @default.
• W2076299286 cites W1996972360 @default.
• W2076299286 cites W2003907692 @default.
• W2076299286 cites W2004498221 @default.
• W2076299286 cites W2008002281 @default.
• W2076299286 cites W2008697182 @default.
• W2076299286 cites W2017146999 @default.
• W2076299286 cites W2017173402 @default.
• W2076299286 cites W2017394727 @default.
• W2076299286 cites W2029197798 @default.
• W2076299286 cites W2031006855 @default.
• W2076299286 cites W2050519979 @default.
• W2076299286 cites W2051877520 @default.
• W2076299286 cites W2054344840 @default.
• W2076299286 cites W2059380567 @default.
• W2076299286 cites W2059465100 @default.
• W2076299286 cites W2064876347 @default.
• W2076299286 cites W2076997401 @default.
• W2076299286 cites W2078927542 @default.
• W2076299286 cites W2093458132 @default.
• W2076299286 cites W2096151993 @default.
• W2076299286 cites W2097811455 @default.
• W2076299286 cites W2106584820 @default.
• W2076299286 cites W2110676296 @default.
• W2076299286 cites W2117383636 @default.
• W2076299286 cites W2123841470 @default.
• W2076299286 cites W2128675289 @default.
• W2076299286 cites W2140334924 @default.
• W2076299286 cites W2152642587 @default.
• W2076299286 cites W2157034871 @default.
• W2076299286 cites W2157287007 @default.
• W2076299286 cites W2166798619 @default.
• W2076299286 cites W3192891376 @default.
• W2076299286 doi "https://doi.org/10.1155/2014/418292" @default.
• W2076299286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4370204" @default.
• W2076299286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25838640" @default.
• W2076299286 hasPublicationYear "2014" @default.
• W2076299286 type Work @default.
• W2076299286 sameAs 2076299286 @default.
• W2076299286 citedByCount "32" @default.
• W2076299286 countsByYear W20762992862014 @default.
• W2076299286 countsByYear W20762992862015 @default.
• W2076299286 countsByYear W20762992862017 @default.
• W2076299286 countsByYear W20762992862018 @default.
• W2076299286 countsByYear W20762992862019 @default.
• W2076299286 countsByYear W20762992862020 @default.
• W2076299286 countsByYear W20762992862021 @default.
• W2076299286 countsByYear W20762992862022 @default.
• W2076299286 countsByYear W20762992862023 @default.
• W2076299286 crossrefType "journal-article" @default.
• W2076299286 hasAuthorship W2076299286A5017637135 @default.
• W2076299286 hasAuthorship W2076299286A5028638344 @default.
• W2076299286 hasAuthorship W2076299286A5042722243 @default.
• W2076299286 hasAuthorship W2076299286A5043451583 @default.
• W2076299286 hasAuthorship W2076299286A5047913787 @default.
• W2076299286 hasAuthorship W2076299286A5050793635 @default.
• W2076299286 hasAuthorship W2076299286A5052933885 @default.
• W2076299286 hasAuthorship W2076299286A5086612276 @default.
• W2076299286 hasBestOaLocation W20762992861 @default.
• W2076299286 hasConcept C153911025 @default.
• W2076299286 hasConcept C154317977 @default.
• W2076299286 hasConcept C167672396 @default.
• W2076299286 hasConcept C202751555 @default.
• W2076299286 hasConcept C203014093 @default.
• W2076299286 hasConcept C2776090121 @default.
• W2076299286 hasConcept C2779341262 @default.
• W2076299286 hasConcept C502942594 @default.
• W2076299286 hasConcept C553184892 @default.
• W2076299286 hasConcept C55493867 @default.
• W2076299286 hasConcept C86803240 @default.
• W2076299286 hasConcept C8891405 @default.
• W2076299286 hasConceptScore W2076299286C153911025 @default.
• W2076299286 hasConceptScore W2076299286C154317977 @default.
• W2076299286 hasConceptScore W2076299286C167672396 @default.
• W2076299286 hasConceptScore W2076299286C202751555 @default.
• W2076299286 hasConceptScore W2076299286C203014093 @default.

• next