FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076300309> ?p ?o ?g. }

• W2076300309 endingPage "1198" @default.
• W2076300309 startingPage "1187" @default.
• W2076300309 abstract "Summary Background Although eosinophils co‐express multiple integrin receptors, the contributions of integrins to eosinophil development have not been explored. We previously described extensive aggregation and cytological immaturity in eosinophils developing in bone‐marrow (BM) cultures exposed to dexamethasone. Here we examined the relationship of α4 integrins with these effects of dexamethasone. Objectives We evaluated: (a) the effects of exposure to dexamethasone in BM culture on eosinophil expression of α4 integrin receptors and ligands; (b) the contribution of α4 integrins to eosinophil aggregation and maturation. Methods Cultures were established with IL‐5 (alone or with dexamethasone) for up to 7 days, and eosinophil production, α4 integrin receptor/ligand expression, aggregation and morphology were evaluated before and after targeting α4 integrin‐dependent adhesions. Because prostaglandin E2 (PGE2) modifies the effects of dexamethasone on eosinophilopoiesis, PGE2 effects on α4 integrin expression and function were also evaluated. Results Dexamethasone increased the yield of eosinophils up to day 7. The frequency of eosinophils expressing α4, β1 and β7 integrin receptors at day 7 was also increased by dexamethasone. Eosinophils also expressed the α4β1 ligand, VCAM‐1. Dexamethasone increased the expression of α4 integrin and VCAM‐1 in aggregates containing eosinophils as early as day 3. PGE2, added up to day 3, modified the effects of dexamethasone to suppress the expression of α4 integrin, decrease aggregation and promote cytological maturation of eosinophils recovered at day 7. Dissociation of immature eosinophils from clusters present at day 3 by reagents targeting α4 or β1 integrins or VCAM‐1 also induced cytological maturation. The concordant effects of targeting α4 integrins with drugs and antibodies support a relationship between α4‐mediated aggregation and maturational arrest. Conclusions These observations support a novel role for α4 integrin receptors and ligands in eosinophilopoiesis. In addition, increased α4 expression following glucocorticoid exposure may contribute to the retention and accumulation of eosinophils in haemopoietic tissue." @default.
• W2076300309 created "2016-06-24" @default.
• W2076300309 creator A5040541882 @default.
• W2076300309 creator A5047738069 @default.
• W2076300309 creator A5059700494 @default.
• W2076300309 creator A5068505786 @default.
• W2076300309 creator A5076611610 @default.
• W2076300309 creator A5081069700 @default.
• W2076300309 date "2009-07-09" @default.
• W2076300309 modified "2023-10-16" @default.
• W2076300309 title "Evidence for a regulatory role of α4 - integrins in the maturation of eosinophils generated from the bone marrow in the presence of dexamethasone" @default.
• W2076300309 cites W1585321805 @default.
• W2076300309 cites W1932316892 @default.
• W2076300309 cites W1965298978 @default.
• W2076300309 cites W1977079535 @default.
• W2076300309 cites W1986311401 @default.
• W2076300309 cites W1991469497 @default.
• W2076300309 cites W1991654676 @default.
• W2076300309 cites W1995446704 @default.
• W2076300309 cites W2003274919 @default.
• W2076300309 cites W2010875184 @default.
• W2076300309 cites W2016572379 @default.
• W2076300309 cites W2043043327 @default.
• W2076300309 cites W2046406951 @default.
• W2076300309 cites W2048032185 @default.
• W2076300309 cites W2053348109 @default.
• W2076300309 cites W2099253390 @default.
• W2076300309 cites W2099545837 @default.
• W2076300309 cites W2109395201 @default.
• W2076300309 cites W2119817843 @default.
• W2076300309 cites W2122096901 @default.
• W2076300309 cites W2125064243 @default.
• W2076300309 cites W2142857719 @default.
• W2076300309 cites W2145070315 @default.
• W2076300309 cites W4240211429 @default.
• W2076300309 cites W4313342410 @default.
• W2076300309 doi "https://doi.org/10.1111/j.1365-2222.2009.03289.x" @default.
• W2076300309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19508325" @default.
• W2076300309 hasPublicationYear "2009" @default.
• W2076300309 type Work @default.
• W2076300309 sameAs 2076300309 @default.
• W2076300309 citedByCount "19" @default.
• W2076300309 countsByYear W20763003092012 @default.
• W2076300309 countsByYear W20763003092013 @default.
• W2076300309 countsByYear W20763003092014 @default.
• W2076300309 countsByYear W20763003092015 @default.
• W2076300309 countsByYear W20763003092017 @default.
• W2076300309 countsByYear W20763003092018 @default.
• W2076300309 countsByYear W20763003092019 @default.
• W2076300309 countsByYear W20763003092020 @default.
• W2076300309 countsByYear W20763003092021 @default.
• W2076300309 countsByYear W20763003092022 @default.
• W2076300309 crossrefType "journal-article" @default.
• W2076300309 hasAuthorship W2076300309A5040541882 @default.
• W2076300309 hasAuthorship W2076300309A5047738069 @default.
• W2076300309 hasAuthorship W2076300309A5059700494 @default.
• W2076300309 hasAuthorship W2076300309A5068505786 @default.
• W2076300309 hasAuthorship W2076300309A5076611610 @default.
• W2076300309 hasAuthorship W2076300309A5081069700 @default.
• W2076300309 hasConcept C126322002 @default.
• W2076300309 hasConcept C134018914 @default.
• W2076300309 hasConcept C170493617 @default.
• W2076300309 hasConcept C185592680 @default.
• W2076300309 hasConcept C195687474 @default.
• W2076300309 hasConcept C203014093 @default.
• W2076300309 hasConcept C2776042228 @default.
• W2076300309 hasConcept C2777037409 @default.
• W2076300309 hasConcept C2780007613 @default.
• W2076300309 hasConcept C2780401358 @default.
• W2076300309 hasConcept C71924100 @default.
• W2076300309 hasConcept C86803240 @default.
• W2076300309 hasConcept C95444343 @default.
• W2076300309 hasConceptScore W2076300309C126322002 @default.
• W2076300309 hasConceptScore W2076300309C134018914 @default.
• W2076300309 hasConceptScore W2076300309C170493617 @default.
• W2076300309 hasConceptScore W2076300309C185592680 @default.
• W2076300309 hasConceptScore W2076300309C195687474 @default.
• W2076300309 hasConceptScore W2076300309C203014093 @default.
• W2076300309 hasConceptScore W2076300309C2776042228 @default.
• W2076300309 hasConceptScore W2076300309C2777037409 @default.
• W2076300309 hasConceptScore W2076300309C2780007613 @default.
• W2076300309 hasConceptScore W2076300309C2780401358 @default.
• W2076300309 hasConceptScore W2076300309C71924100 @default.
• W2076300309 hasConceptScore W2076300309C86803240 @default.
• W2076300309 hasConceptScore W2076300309C95444343 @default.
• W2076300309 hasIssue "8" @default.
• W2076300309 hasLocation W20763003091 @default.
• W2076300309 hasLocation W20763003092 @default.
• W2076300309 hasOpenAccess W2076300309 @default.
• W2076300309 hasPrimaryLocation W20763003091 @default.
• W2076300309 hasRelatedWork W1982434602 @default.
• W2076300309 hasRelatedWork W2094844283 @default.
• W2076300309 hasRelatedWork W2354241142 @default.
• W2076300309 hasRelatedWork W2365729717 @default.
• W2076300309 hasRelatedWork W2372664423 @default.
• W2076300309 hasRelatedWork W2387893491 @default.
• W2076300309 hasRelatedWork W2388510727 @default.
• W2076300309 hasRelatedWork W2944534848 @default.

• next